2024
Longitudinal Patterns of Systolic Blood Pressure, Diastolic Blood Pressure, Cardiorespiratory Fitness, and Their Association With Dementia Risk: The HUNT Study
Lerfald M, Allore H, Nilsen T, Eldholm R, Martinez-Velilla N, Selbæk G, Ernstsen L. Longitudinal Patterns of Systolic Blood Pressure, Diastolic Blood Pressure, Cardiorespiratory Fitness, and Their Association With Dementia Risk: The HUNT Study. The Journals Of Gerontology Series A 2024, 79: glae161. PMID: 38894618, PMCID: PMC11266981, DOI: 10.1093/gerona/glae161.Peer-Reviewed Original ResearchEstimated cardiorespiratory fitnessCardiorespiratory fitnessDementia riskHUNT StudyRisk differenceAssociated with reduced dementia riskPopulation-based HUNT StudyAssociated with dementia riskOdds ratioPoor cardiorespiratory fitnessHigher cardiorespiratory fitnessRisk of dementiaEstimate odds ratiosRisk factorsModifiable risk factorsAge groupsAPOE e4 statusProspective cohort studyBlood pressureMultivariate logistic regressionHigh blood pressureMiddle-aged groupLongitudinal patternsE4 statusSystolic blood pressure
2023
EARLY-LIFE CIRCUMSTANCES AND RACIAL DISPARITIES IN COGNITION AMONG US OLDER ADULTS
Lin Z, Ye J, Allore H, Gill T, Chen X. EARLY-LIFE CIRCUMSTANCES AND RACIAL DISPARITIES IN COGNITION AMONG US OLDER ADULTS. Innovation In Aging 2023, 7: 304-304. PMCID: PMC10735771, DOI: 10.1093/geroni/igad104.1011.Peer-Reviewed Original ResearchRACIAL/ETHNIC AND MULTIMORBIDITY DIFFERENCES IN DEMENTIA ONSET AMONG MIDDLE-AGED AND OLDER ADULTS
Chen S, Nagel C, Botoseneanu A, Allore H, Newsom J, Thielke S, Kaye J, Quiñones A. RACIAL/ETHNIC AND MULTIMORBIDITY DIFFERENCES IN DEMENTIA ONSET AMONG MIDDLE-AGED AND OLDER ADULTS. Innovation In Aging 2023, 7: 747-747. PMCID: PMC10737488, DOI: 10.1093/geroni/igad104.2416.Peer-Reviewed Original ResearchDementia onsetRace/ethnicityHigh riskOlder adultsModifiable risk factorsNon-Hispanic blacksCovariate-adjusted modelsContext of multimorbidityNon-Hispanic white respondentsNon-Hispanic White older adultsWhite older adultsRacial/EthnicMultimorbidity combinationsRisk factorsDiscrete-time survival modelsHigh prevalenceHigher oddsMultimorbidityWhite adultsDementiaMiddle AgedLater lifeAdultsSignificant differencesRiskAging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Young J, Park H, Kim M, Par-Young J, Bartlett H, Kim H, Unlu S, Osmani L, Shin M, Bucala R, van Dyck C, Allore H, Mecca A, You S, Kang I. Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease. Immunity & Ageing 2023, 20: 71. PMID: 38042785, PMCID: PMC10693128, DOI: 10.1186/s12979-023-00396-y.Peer-Reviewed Original ResearchPeripheral bloodT cellsAlzheimer's diseaseEM CD8Memory CD8Gene signatureAge-related immune changesIL-7 receptor alphaEffector memory CD8Strong risk factorT cell expansionAD genesAge-associated expansionImmune changesRisk factorsCD8Dementia patientsIL-7RNeuropsychological testingReceptor alphaNeurocognitive functionRT-qPCR resultsDisease severityPatientsNormal personsThe association of electronic health literacy with behavioural and psychological coronary artery disease risk factors in patients after percutaneous coronary intervention: a 12-month follow-up study
Brørs G, Dalen H, Allore H, Deaton C, Fridlund B, Norman C, Palm P, Wentzel-Larsen T, Norekvål T. The association of electronic health literacy with behavioural and psychological coronary artery disease risk factors in patients after percutaneous coronary intervention: a 12-month follow-up study. European Heart Journal - Digital Health 2023, 4: 125-135. PMID: 36974270, PMCID: PMC10039428, DOI: 10.1093/ehjdh/ztad010.Peer-Reviewed Original ResearchPercutaneous coronary interventionCoronary artery disease risk factorsCAD risk factorsDisease risk factorsLow eHealth literacyRisk factorsElectronic health literacyCoronary interventionEHealth literacyHealth informationHealth literacyHigh-risk CAD patientsEHealth resourcesLow physical activityProspective longitudinal studyIndex admissionAdult patientsCAD patientsEHealth Literacy ScaleHigh burdenPhysical activityPatient useDepression symptomsPatientsLow burden
2022
RACIAL-ETHNIC VARIATION IN MULTIMORBIDITY PATTERNS AND HEALTHCARE SERVICES AMONG OLDEST-OLD PATIENTS
Cho J, Rahimighazikalayeh G, Allore H. RACIAL-ETHNIC VARIATION IN MULTIMORBIDITY PATTERNS AND HEALTHCARE SERVICES AMONG OLDEST-OLD PATIENTS. Innovation In Aging 2022, 6: 795-795. PMCID: PMC9767161, DOI: 10.1093/geroni/igac059.2870.Peer-Reviewed Original ResearchMultiple chronic conditionsOldest-old patientsHealthcare service utilizationPatterns of multimorbidityClinic visitsEmergency departmentHispanic patientsService utilizationHealthcare systemAge-related risk factorsIntegrated healthcare systemRacial-ethnic variationsMetabolism syndromeWhite patientsBlack patientsMultimorbidity patternsChronic conditionsRisk factorsClinical dataPatientsCare managementAlzheimer's diseaseDiverse patientsRelated dementiaSignificant associationHealth Literacy and Risk Factors for Coronary Artery Disease (From the CONCARDPCI Study)
Brørs G, Dalen H, Allore H, Deaton C, Fridlund B, Osborne RH, Palm P, Wentzel-Larsen T, Norekvål TM, investigators C. Health Literacy and Risk Factors for Coronary Artery Disease (From the CONCARDPCI Study). The American Journal Of Cardiology 2022, 179: 22-30. PMID: 35853782, DOI: 10.1016/j.amjcard.2022.06.016.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePercutaneous coronary interventionPsychologic risk factorsCAD risk factorsRisk factorsHealth literacyIndex admissionArtery diseaseLower health literacy scoresSecondary prevention careMulticenter cohort studyBehavioral risk factorsHealth Literacy QuestionnaireHealth literacy scoresLow health literacyWeekly physical activityHealth Literacy ScaleHealth literacy challengesPrevention careCohort studyCoronary interventionPoor outcomePhysical activityDepression symptomsLarger studyRisk Factors of Skilled Nursing Facility Admissions and the Interrelation With Hospitalization and Amount of Informal Caregiving Received
Cao Y, Allore H, Gutman R, Vander Wyk B, Jørgensen TSH. Risk Factors of Skilled Nursing Facility Admissions and the Interrelation With Hospitalization and Amount of Informal Caregiving Received. Medical Care 2022, 60: 294-301. PMID: 35149662, PMCID: PMC8916995, DOI: 10.1097/mlr.0000000000001697.Peer-Reviewed Original ResearchConceptsSkilled nursing facility admissionsNursing facility admissionsNumber of hospitalizationsSNF admissionImportant risk factorRisk factorsHospital admissionFacility admissionNon-Hispanic white race/ethnicityWhite race/ethnicityInformal caregivingWeak positive correlationDaily living (ADL) disabilityPossible risk factorsPositive correlationAging Trends StudyRace/ethnicityObservational followStrong positive correlationNational HealthAdmissionDementia diagnosisHospitalizationAlzheimer's diseaseHealth factors
2018
A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity
Zhang C, Ramsey C, Berical A, Yu L, Leng L, McGinnis K, Song Y, Michael H, McCormack M, Allore H, Morris A, Crothers K, Bucala R, Lee P, Sauler M. A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2018, 316: l400-l405. PMID: 30520689, PMCID: PMC6397351, DOI: 10.1152/ajplung.00439.2018.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorChronic obstructive pulmonary diseaseMIF -794 CATTAbnormal diffusion capacityCigarette smoke exposureSmoke exposureAssociation of MIFDiffusion capacityMacrophage migration inhibitory factor (MIF) promoter polymorphismsPathogenesis of COPDChronic cigarette smoke exposureMultivariable logistic regression modelModifiable risk factorsObstructive pulmonary diseaseMigration inhibitory factorCross-sectional analysisLogistic regression modelsCommon genetic polymorphismsInnate immune genesAirflow obstructionMIF expressionCOPD severityPulmonary diseaseMIF allelesRisk factors
2013
Modifiable Risk Factors for Pneumonia Requiring Hospitalization of Community‐Dwelling Older Adults: The Health, Aging, and Body Composition Study
Juthani‐Mehta M, De Rekeneire N, Allore H, Chen S, O'Leary JR, Bauer DC, Harris TB, Newman AB, Yende S, Weyant RJ, Kritchevsky S, Quagliarello V, Study F. Modifiable Risk Factors for Pneumonia Requiring Hospitalization of Community‐Dwelling Older Adults: The Health, Aging, and Body Composition Study. Journal Of The American Geriatrics Society 2013, 61: 1111-1118. PMID: 23772872, PMCID: PMC3714374, DOI: 10.1111/jgs.12325.Peer-Reviewed Original ResearchConceptsModifiable risk factorsIncident mobility limitationCommunity-dwelling older adultsBody Composition StudyRisk factorsPlaque scoresMobility limitationsOlder adultsNovel modifiable risk factorsProspective observational cohort studyObservational cohort studyNonmodifiable risk factorsCases of pneumoniaHistory of pneumoniaCommunity-dwelling adultsAverage attributable fractionMonths of baselineCohort studyExpiratory volumePneumonia preventionDental examinationPrimary outcomeOral hygieneMale sexAttributable fraction
2012
A method for partitioning the attributable fraction of multiple time-dependent coexisting risk factors for an adverse health outcome.
Lin H, Allore HG, McAvay G, Tinetti ME, Gill TM, Gross CP, Murphy TE. A method for partitioning the attributable fraction of multiple time-dependent coexisting risk factors for an adverse health outcome. American Journal Of Public Health 2012, 103: 177-82. PMID: 22515873, PMCID: PMC3518339, DOI: 10.2105/ajph.2011.300458.Peer-Reviewed Original ResearchConceptsHealth outcomesAttributable fraction methodPrecipitating Events ProjectAdverse health outcomesMultiple diseasesAcute episodeNew onsetHeart failureAdverse outcomesRisk factorsAttributable fractionNew Haven CountyDiseaseIndividual diseasesOlder adultsOutcomesAdditive effectDeathEvent outcomesOnsetPneumoniaCohort
2009
Pilot Testing of Intervention Protocols to Prevent Pneumonia in Nursing Home Residents
Quagliarello V, Juthani‐Mehta M, Ginter S, Towle V, Allore H, Tinetti M. Pilot Testing of Intervention Protocols to Prevent Pneumonia in Nursing Home Residents. Journal Of The American Geriatrics Society 2009, 57: 1226-1231. PMID: 19558483, PMCID: PMC2779042, DOI: 10.1111/j.1532-5415.2009.02311.x.Peer-Reviewed Original ResearchConceptsNursing home residentsChlorhexidine oral rinseOral brushingHome residentsOral hygieneStaff adherenceOral rinseIntervention protocolImproved oral hygienePneumonia risk factorsRisk factor reductionPlaque score reductionPrevent PneumoniaChlorhexidine rinseProspective studyRisk factorsScore reductionNursing homesSwallowing techniquesAdherenceBrushingFactor reductionPneumoniaHygieneMonths
2008
Review: An examination of effect estimation in factorial and standardly-tailored designs
Allore HG, Murphy TE. Review: An examination of effect estimation in factorial and standardly-tailored designs. Clinical Trials 2008, 5: 121-130. PMID: 18375650, PMCID: PMC3477845, DOI: 10.1177/1740774508089278.Peer-Reviewed Original ResearchConceptsInterventional componentsRisk factorsClinical trialsTranslational researchMulticomponent interventionIndividual component effectsRandomized clinical trialsMultiple intervention componentsInterventional trialsGeriatric conditionsIntervention armTreatment armsControl armTrial designHealth outcomesIntervention componentsTrialsMedical communityInterventionSignificant findingsArmSubjectsCurrent inabilityNet effectGeriatrics
2005
Experimental designs for multicomponent interventions among persons with multifactorial geriatric syndromes
Allore HG, Tinettia M, Gill TM, Peduzzi PN. Experimental designs for multicomponent interventions among persons with multifactorial geriatric syndromes. Clinical Trials 2005, 2: 13-21. PMID: 16279575, DOI: 10.1191/1740774505cn067oa.Peer-Reviewed Original ResearchConceptsMultifactorial health conditionsModifiable risk factorsMulticomponent interventionRisk factorsGeriatric syndromesHealth conditionsMultifactorial geriatric syndromeOutcomes of interestIntervention trialsClinical trialsClinical concernIntervention componentsInterventionSyndromeDeleterious effectsTrialsOutcomesBlindingFactors