2024
The extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries
Dorr D, Markwardt S, Bobo M, Allore H, Botoseneanu A, Newsom J, Nagel C, Quiñones A. The extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries. BMC Geriatrics 2024, 24: 777. PMID: 39304796, PMCID: PMC11414248, DOI: 10.1186/s12877-024-05329-y.Peer-Reviewed Original ResearchConceptsHigh multimorbidityMultimorbidity levelOlder adultsHigher levels of multimorbidityHealth and Retirement Study dataAssociated with sociodemographic characteristicsWell-being of older adultsLevels of multimorbidityProgression of multimorbidityImpact of multimorbidityBurden of multimorbidityHigher healthcare utilizationRetirement Study dataYounger birth cohortsMultimorbidity groupsHealthcare utilizationLower educationNon-HispanicMultimorbiditySociodemographic characteristicsMedicare beneficiariesSocioeconomic statusHealth indicatorsBirth cohortChronic diseasesResiliency among older adults receiving lung cancer treatment (ROAR-LCT): A novel supportive care intervention for older adults with advanced lung cancer
Presley C, Grogan M, Compston A, Hock K, Knauss B, Redder E, Arrato N, Lo S, Janse S, Benedict J, Hoyd R, Williams N, Hayes S, Wells-Di Gregorio S, Gill T, Allore H, Focht B, Quist M, Carbone D, Spakowicz D, Paskett E, Andersen B. Resiliency among older adults receiving lung cancer treatment (ROAR-LCT): A novel supportive care intervention for older adults with advanced lung cancer. Journal Of Geriatric Oncology 2024, 15: 101844. PMID: 39174449, DOI: 10.1016/j.jgo.2024.101844.Peer-Reviewed Original ResearchShort Physical Performance BatterySupportive care interventionsProgressive muscle relaxationPhysical therapyCare interventionsOlder adultsVirtual healthSelf-report measures of functional statusTwo-minute walk testPatient Health Questionnaire-9Functional statusMeasures of functional statusAdvanced lung cancerGeneralized Anxiety Disorder-7Physical Performance BatteryActivity monitor dataEQ-5D-5LEvaluated in-personParticipants' functional statusCancer treatmentHealth sessionsPerformance BatteryResistance bandsPost-interventionWalk testMultimorbidity and associated informal care receiving characteristics for US older adults: a latent class analysis
Liu R, Nagel C, Chen S, Newsom J, Allore H, Quiñones A. Multimorbidity and associated informal care receiving characteristics for US older adults: a latent class analysis. BMC Geriatrics 2024, 24: 571. PMID: 38956501, PMCID: PMC11221032, DOI: 10.1186/s12877-024-05158-z.Peer-Reviewed Original ResearchConceptsNational Health and Aging Trends StudyMultimorbidity patternsCare needsOlder adultsSelf-careInformal careLatent class analysisCare receiver characteristicsCombinations of multimorbidityPerson-centered carePatterns of multimorbidityDifferential care needsUS older adultsAssociated with lower oddsAssociated with higher oddsGroup of older adultsMultinomial logistic regression modelModerate cognitive impairmentClass analysisLogistic regression modelsInformal caregiversBackgroundOlder adultsCare recipientsMultimorbidity groupsChronic conditionsMental-somatic multimorbidity in trajectories of cognitive function for middle-aged and older adults
Chen S, Nagel C, Liu R, Botoseneanu A, Allore H, Newsom J, Thielke S, Kaye J, Quiñones A. Mental-somatic multimorbidity in trajectories of cognitive function for middle-aged and older adults. PLOS ONE 2024, 19: e0303599. PMID: 38743678, PMCID: PMC11093294, DOI: 10.1371/journal.pone.0303599.Peer-Reviewed Original ResearchConceptsOdds of cognitive impairmentGroup-based trajectory modelingMultimorbidity combinationsLate-life increaseOlder adultsNon-Hispanic white adultsHigh riskHealth and Retirement StudyMiddle-agedHealth-related factorsTrajectories of cognitive functionCognitive declineCognitive impairmentMultinomial logistic regression modelMultinomial logistic regression analysisLow riskLogistic regression modelsLow initial riskTrajectory group membershipLogistic regression analysisRetirement StudyNon-HispanicMultimorbidityWhite adultsHispanic respondentsLongitudinal Care Network Changes and Associated Healthcare Utilization Among Care Recipients
Liu R, Vander Wyk B, Quiñones A, Allore H. Longitudinal Care Network Changes and Associated Healthcare Utilization Among Care Recipients. Research On Aging 2024, 46: 327-338. PMID: 38261524, PMCID: PMC11472584, DOI: 10.1177/01640275241229162.Peer-Reviewed Original ResearchSkilled-nursing facilityCare recipientsNational Health and Aging Trends StudyGeneralized estimating equation modelsCenters for MedicareLikelihood of hospitalizationMedicaid Services dataCaregiver networkUnpaid caregiversHealthcare utilizationTrends StudyAssociated healthcare utilizationOlder adultsCaregiversRisk ratioSurvey wavesService dataCareHospitalAssociationAdmissionMedicareMedicaidAdultsEquation modeling
2023
EARLY-LIFE CIRCUMSTANCES AND RACIAL DISPARITIES IN COGNITION AMONG US OLDER ADULTS
Lin Z, Ye J, Allore H, Gill T, Chen X. EARLY-LIFE CIRCUMSTANCES AND RACIAL DISPARITIES IN COGNITION AMONG US OLDER ADULTS. Innovation In Aging 2023, 7: 304-304. PMCID: PMC10735771, DOI: 10.1093/geroni/igad104.1011.Peer-Reviewed Original ResearchTHE EFFECT OF CHRONIC CONDITIONS ON DEPRESSIVE SYMPTOMS IS MODERATED BY SEXUAL MINORITY STATUS
Trubits E, Newsom J, Saucedo J, Botoseneanu A, Allore H, Nagel C, Dorr D, Quiñones A. THE EFFECT OF CHRONIC CONDITIONS ON DEPRESSIVE SYMPTOMS IS MODERATED BY SEXUAL MINORITY STATUS. Innovation In Aging 2023, 7: 797-798. PMCID: PMC10737157, DOI: 10.1093/geroni/igad104.2574.Peer-Reviewed Original ResearchSelf-rated healthGreater depressive symptomsChronic conditionsDepressive symptomsOlder adultsEffect of SRHGood self-rated healthRace/ethnicityMinority older adultsYears of educationSymptomsHealth disparitiesMental healthPhysical healthSM adultsAdultsRetirement StudyHealthSexual minority statusDirect effectParticipant sexSame effectGreater numberDisparitiesRACIAL/ETHNIC AND MULTIMORBIDITY DIFFERENCES IN DEMENTIA ONSET AMONG MIDDLE-AGED AND OLDER ADULTS
Chen S, Nagel C, Botoseneanu A, Allore H, Newsom J, Thielke S, Kaye J, Quiñones A. RACIAL/ETHNIC AND MULTIMORBIDITY DIFFERENCES IN DEMENTIA ONSET AMONG MIDDLE-AGED AND OLDER ADULTS. Innovation In Aging 2023, 7: 747-747. PMCID: PMC10737488, DOI: 10.1093/geroni/igad104.2416.Peer-Reviewed Original ResearchDementia onsetRace/ethnicityHigh riskOlder adultsModifiable risk factorsNon-Hispanic blacksCovariate-adjusted modelsContext of multimorbidityNon-Hispanic white respondentsNon-Hispanic White older adultsWhite older adultsRacial/EthnicMultimorbidity combinationsRisk factorsDiscrete-time survival modelsHigh prevalenceHigher oddsMultimorbidityWhite adultsDementiaMiddle AgedLater lifeAdultsSignificant differencesRiskCARE-RECEIVING CHARACTERISTICS AMONG OLDER ADULTS WITH DIFFERENT MENTAL–SOMATIC MULTIMORBIDITY COMBINATIONS
Liu M, Nagel C, Chen S, Allore H, Kaye J, Quiñones A. CARE-RECEIVING CHARACTERISTICS AMONG OLDER ADULTS WITH DIFFERENT MENTAL–SOMATIC MULTIMORBIDITY COMBINATIONS. Innovation In Aging 2023, 7: 821-821. PMCID: PMC10738666, DOI: 10.1093/geroni/igad104.2648.Peer-Reviewed Original ResearchCognitive impairmentCognitive impairment groupMultimorbidity combinationsOlder adultsDepression groupMore caregiversImpairment groupLower self-rated healthSomatic conditionsNon-Hispanic blacksCombination of depressionSelf-rated healthMore functional limitationsAging Trends StudyMore hoursMultimorbidity patternsUnderweight BMINational HealthFunctional limitationsMedicaid recipientsHealth outcomesDifferent careMental healthImpairmentDepressionLATENT CLASSES OF MULTIMORBIDITY AND ASSOCIATED CARE-RECEIVING CHARACTERISTICS FOR US OLDER ADULTS
Liu M, Nagel C, Chen S, Kaye J, Allore H, Quiñones A. LATENT CLASSES OF MULTIMORBIDITY AND ASSOCIATED CARE-RECEIVING CHARACTERISTICS FOR US OLDER ADULTS. Innovation In Aging 2023, 7: 823-823. PMCID: PMC10739216, DOI: 10.1093/geroni/igad104.2654.Peer-Reviewed Original ResearchOlder adultsCare needsMore unmet needsDifferent care needsType of careAging Trends StudyMultimorbidity combinationsMultimorbidity patternsMusculoskeletal conditionsChronic conditionsNational HealthMedian numberUnmet needAssociated careMultimorbidityCareIADL domainsLatent classesAbstract Older adultsAdultsFurther investigationFour-class solutionHealthy classCaregiversSmall proportionPhenotyping Self-Reported Health Profiles in Octogenarians and Nonagenarians After Percutaneous Coronary Intervention: A Latent Profile Analysis
Instenes I, Breivik K, Borregaard B, Larsen A, Allore H, Bendz B, Deaton C, Rotevatn S, Norekvål T, investigators C. Phenotyping Self-Reported Health Profiles in Octogenarians and Nonagenarians After Percutaneous Coronary Intervention: A Latent Profile Analysis. Heart Lung And Circulation 2023, 32: 1321-1333. PMID: 37925313, DOI: 10.1016/j.hlc.2023.09.004.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPoor health profileBetter health profileSelf-reported healthLow exercise levelsHealth profileCoronary interventionExercise levelsOlder adultsLow alcohol intakeLogistic regression analysisReal-world studyDifferent health outcomesMultinomial logistic regression analysisPatient characteristicsAlcohol intakeHealth outcomesHealth statusOctogenariansOlder ageNonagenariansMost participantsMonthsRegression analysisStandardised measuresA Joint Model for Disability, Self-Rated Health, and Mortality Among Medicare Beneficiaries—Differences by Chronic Disease and Race/Ethnicity
Quiñones A, McAvay G, Vander Wyk B, Han L, Nagel C, Allore H. A Joint Model for Disability, Self-Rated Health, and Mortality Among Medicare Beneficiaries—Differences by Chronic Disease and Race/Ethnicity. Journal Of Aging And Health 2023, 36: 642-653. PMID: 37879084, PMCID: PMC11446605, DOI: 10.1177/08982643231210027.Peer-Reviewed Original ResearchPoor self-rated healthSelf-rated healthHigher oddsADL disabilityHip fractureAging Trends Study dataOlder adultsConcurrent riskPatient-centered outcomesLongitudinal logistic regression modelsLogistic regression modelsRace/ethnicityKidney diseaseChronic diseasesNational HealthDaily livingMortalityHealth declineOddsDisabilityHispanic respondentsDementiaDiseaseRiskWide variabilityDectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging
Kumar A, Wang J, Esterly A, Radcliffe C, Zhou H, Wyk B, Allore H, Tsang S, Barakat L, Mohanty S, Zhao H, Shaw A, Zapata H. Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging. Aging 2023, 15: 7866-7908. PMID: 37606991, PMCID: PMC10497004, DOI: 10.18632/aging.204927.Peer-Reviewed Original ResearchConceptsDectin-1 stimulationDendritic cellsHIV-positive older adultsOlder adultsDectin-1 functionDistinct immune signaturesDistinct inflammatory signatureMonocytes of HIVCohort of HIVIFN-α productionPro-inflammatory environmentIFN-γ responsesPro-inflammatory phenotypeInnate immune receptorsDistinct gene signaturesStimulation of monocytesInflammatory signatureImmune signaturesHIV infectionIL-12Macrophage signatureCytokine productionIL-6Cytokine increaseHIVAssociations between dementia staging, neuropsychiatric behavioral symptoms, and divorce or separation in late life: A case control study
Monin J, McAvay G, Zang E, Vander Wyk B, Carrión C, Allore H. Associations between dementia staging, neuropsychiatric behavioral symptoms, and divorce or separation in late life: A case control study. PLOS ONE 2023, 18: e0289311. PMID: 37585365, PMCID: PMC10431668, DOI: 10.1371/journal.pone.0289311.Peer-Reviewed Original ResearchConceptsAdjusted odds ratioAlzheimer's Disease Research CenterAgitation/aggressionDepression/dysphoriaCase-control studyElation/euphoriaNational Alzheimer's Coordinating CenterDisease Research CenterBehavioral symptomsDivorce/separationOlder adultsCoordinating CenterDementia stagingConditional logistic regressionStages of dementiaCase/control statusInitial visitOdds ratioIndividual symptomsNPI scoresStandardized clinical informationClinical informationMarried casesGreater oddsControl studyAntibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdultsPlatelet response to influenza vaccination reflects effects of aging
Konstorum A, Mohanty S, Zhao Y, Melillo A, Vander Wyk B, Nelson A, Tsang S, Blevins T, Belshe R, Chawla D, Rondina M, Gill T, Montgomery R, Allore H, Kleinstein S, Shaw A. Platelet response to influenza vaccination reflects effects of aging. Aging Cell 2023, 22: e13749. PMID: 36656789, PMCID: PMC9924941, DOI: 10.1111/acel.13749.Peer-Reviewed Original ResearchConceptsCommunity-dwelling older adultsPlatelet activationOlder adultsInfluenza vaccinationAge-associated chronic inflammationInfluence platelet functionRNA expressionPro-inflammatory diseasesAge-associated increasePlatelet activation pathwaysAge-associated differencesActivation pathwayPlatelet transcriptomeGeriatric conditionsChronic inflammationImmune responsePlatelet functionPlatelet responseSNF residentsVaccinationActivation responseYoung individualsProtein levelsAdultsYounger participants
2022
SOCIAL SUPPORT AND STRAIN AS PREDICTORS OF MULTIMORBIDITY FOLLOWING A MARITAL TRANSITION
Denning E, Newsom J, Botoseneanu A, Allore H, Nagel C, Dorr D, Quiñones A. SOCIAL SUPPORT AND STRAIN AS PREDICTORS OF MULTIMORBIDITY FOLLOWING A MARITAL TRANSITION. Innovation In Aging 2022, 6: 567-567. PMCID: PMC9770881, DOI: 10.1093/geroni/igac059.2136.Peer-Reviewed Original ResearchMore chronic conditionsChronic conditionsPredictors of multimorbiditySocial supportAdults age 50Race/ethnicityAge 50Multimorbidity trajectoriesOlder adultsMarital transitionsHealth declineSocial strainStressful eventsRetirement StudyChildrenSpousal supportGrowth curve modelingPiecewise growth curve modelingHealthLtParticipantsMultimorbidityMENTAL-SOMATIC MULTIMORBIDITY IN GROUP-BASED TRAJECTORIES OF COGNITIVE FUNCTION FOR MIDDLE-AGED AND OLDER ADULTS
Chen S, Nagel C, Botoseneanu A, Allore H, Newsom J, Thielke S, Kaye J, Quiñones A. MENTAL-SOMATIC MULTIMORBIDITY IN GROUP-BASED TRAJECTORIES OF COGNITIVE FUNCTION FOR MIDDLE-AGED AND OLDER ADULTS. Innovation In Aging 2022, 6: 610-610. PMCID: PMC9770737, DOI: 10.1093/geroni/igac059.2273.Peer-Reviewed Original ResearchLow baseline riskMultimorbidity combinationsBaseline riskCognitive impairmentSomatic multimorbidityHigher oddsHigher baseline riskCognitive impairment riskCognitive performanceGroup-based trajectory modelingRisk modificationSubsequent riskMultimorbiditySociodemographic factorsMental multimorbidityCognitive declineCognitive functionMiddle AgedOlder adultsImpairment riskImpairmentTrajectory class membershipRiskStrokeRetirement StudyMULTIMORBIDITY PROGRESSION AMONG MEDICARE BENEFICIARIES IN THE HEALTH AND RETIREMENT STUDY (1991–2015)
Quiñones A, Markwardt S, Bobo M, Allore H, Newsom J, Nagel C, Botoseneanu A, Dorr D. MULTIMORBIDITY PROGRESSION AMONG MEDICARE BENEFICIARIES IN THE HEALTH AND RETIREMENT STUDY (1991–2015). Innovation In Aging 2022, 6: 693-693. DOI: 10.1093/geroni/igac059.2540.Peer-Reviewed Original ResearchMultimorbidity groupObese body mass indexOlder adultsLevel of multimorbidityBody mass indexHigh incidence rateHigh multimorbidityMass indexIncidence rateED ratesMultimorbidityMedicare beneficiariesMedicare feeBirth cohortService beneficiariesLower multimorbidityFunctional lossGreater riskSociodemographic differencesDisease accumulationLater lifeAbstract Older adultsRetirement StudyHigher proportionAdultsGERONTOLOGIC BIOSTATISTICS: MERGING WITH DATA SCIENCE AND TOWARD PERSONALIZED MEDICINE
Shardell M, Murphy T, Allore H. GERONTOLOGIC BIOSTATISTICS: MERGING WITH DATA SCIENCE AND TOWARD PERSONALIZED MEDICINE. Innovation In Aging 2022, 6: 177-177. PMCID: PMC9770254, DOI: 10.1093/geroni/igac059.708.Peer-Reviewed Original ResearchStudy of older personsEpidemiology of agingHealth-related interventionsAssessment of healthHeterogeneity of treatment effectsOlder personsOlder adultsIndividual sessionsTreatment effectsOlder patientsMultifactorial naturePublished studiesData scienceSessionsMultiple streams of dataStreams of dataMultimodal approachPersonalized medicineProgressive deteriorationIntegration of data scienceBehavioral phenotypesPatientsAgeInteractive visualizationPractice