2024
The extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries
Dorr D, Markwardt S, Bobo M, Allore H, Botoseneanu A, Newsom J, Nagel C, Quiñones A. The extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries. BMC Geriatrics 2024, 24: 777. PMID: 39304796, PMCID: PMC11414248, DOI: 10.1186/s12877-024-05329-y.Peer-Reviewed Original ResearchConceptsHigh multimorbidityMultimorbidity levelOlder adultsHigher levels of multimorbidityHealth and Retirement Study dataAssociated with sociodemographic characteristicsWell-being of older adultsLevels of multimorbidityProgression of multimorbidityImpact of multimorbidityBurden of multimorbidityHigher healthcare utilizationRetirement Study dataYounger birth cohortsMultimorbidity groupsHealthcare utilizationLower educationNon-HispanicMultimorbiditySociodemographic characteristicsMedicare beneficiariesSocioeconomic statusHealth indicatorsBirth cohortChronic diseasesMental-somatic multimorbidity in trajectories of cognitive function for middle-aged and older adults
Chen S, Nagel C, Liu R, Botoseneanu A, Allore H, Newsom J, Thielke S, Kaye J, Quiñones A. Mental-somatic multimorbidity in trajectories of cognitive function for middle-aged and older adults. PLOS ONE 2024, 19: e0303599. PMID: 38743678, PMCID: PMC11093294, DOI: 10.1371/journal.pone.0303599.Peer-Reviewed Original ResearchConceptsOdds of cognitive impairmentGroup-based trajectory modelingMultimorbidity combinationsLate-life increaseOlder adultsNon-Hispanic white adultsHigh riskHealth and Retirement StudyMiddle-agedHealth-related factorsTrajectories of cognitive functionCognitive declineCognitive impairmentMultinomial logistic regression modelMultinomial logistic regression analysisLow riskLogistic regression modelsLow initial riskTrajectory group membershipLogistic regression analysisRetirement StudyNon-HispanicMultimorbidityWhite adultsHispanic respondentsRecommendations on Methods for Assessing Multimorbidity Changes Over Time: Aligning the Method to the Purpose
Nagel C, Bishop N, Botoseneanu A, Allore H, Newsom J, Dorr D, Quiñones A. Recommendations on Methods for Assessing Multimorbidity Changes Over Time: Aligning the Method to the Purpose. The Journals Of Gerontology Series A 2024, 79: glae122. PMID: 38742711, PMCID: PMC11163923, DOI: 10.1093/gerona/glae122.Peer-Reviewed Original ResearchConceptsStudy of multimorbidityHealth-related quality of lifeMeasures of multimorbidityEffect of multimorbidityPerson-centered outcomesHealth-related outcomesHealth-related qualityLongitudinal studyQuality of lifeHealth-related dataMultimorbidity researchHealth domainsMultimorbidityLate-lifePeriod of changeAging populationOperationalizing changeLongitudinal analysisLongitudinal changesMore advanced stagesQuantitative studyOutcomesResearch objectHealthPractical issuesMultimorbidity Patterns, Hospital Uses and Mortality by Race and Ethnicity Among Oldest-Old Patients
Cho J, Allore H, Rahimighazikalayeh G, Vaughn I. Multimorbidity Patterns, Hospital Uses and Mortality by Race and Ethnicity Among Oldest-Old Patients. Journal Of Racial And Ethnic Health Disparities 2024, 1-10. PMID: 38381325, DOI: 10.1007/s40615-024-01929-x.Peer-Reviewed Original ResearchOldest-old patientsClinic visitsAssociated with EDHealthcare systemEmergency departmentPatterns of multimorbidityHealthcare service utilizationIntegrated healthcare systemGeneralized estimating equationsRacial-ethnic groupsMultimorbidity patternsMultimorbidity clustersMinoritized patientsEmergency careService utilizationProportional hazards survival modelChronic conditionsOldest-oldHospital useDiverse patientsMultimorbidityAge-related risk factorsHospital servicesRace-ethnicityRacial-ethnic variations
2023
SEQUENCE ANALYSIS OF CARDIOMETABOLIC MULTIMORBIDITY AND ASSOCIATION WITH SUBSEQUENT DEMENTIA
Nagel C, Allore H, Botoseneanu A, Kaye J, Newsom J, Bishop N, Quiñones A. SEQUENCE ANALYSIS OF CARDIOMETABOLIC MULTIMORBIDITY AND ASSOCIATION WITH SUBSEQUENT DEMENTIA. Innovation In Aging 2023, 7: 230-231. PMCID: PMC10736019, DOI: 10.1093/geroni/igad104.0758.Peer-Reviewed Original ResearchIncident cardiometabolic diseaseCardiometabolic multimorbidityCardiometabolic diseasesMyocardial infarctionSubsequent dementiaHeart diseaseSelf-reported diagnosisAging Trends StudyBaseline diseasePrior diseaseIncident diseaseNational HealthMultimorbidityMultimorbidity researchDiseaseCognitive healthRACIAL/ETHNIC AND MULTIMORBIDITY DIFFERENCES IN DEMENTIA ONSET AMONG MIDDLE-AGED AND OLDER ADULTS
Chen S, Nagel C, Botoseneanu A, Allore H, Newsom J, Thielke S, Kaye J, Quiñones A. RACIAL/ETHNIC AND MULTIMORBIDITY DIFFERENCES IN DEMENTIA ONSET AMONG MIDDLE-AGED AND OLDER ADULTS. Innovation In Aging 2023, 7: 747-747. PMCID: PMC10737488, DOI: 10.1093/geroni/igad104.2416.Peer-Reviewed Original ResearchDementia onsetRace/ethnicityHigh riskOlder adultsModifiable risk factorsNon-Hispanic blacksCovariate-adjusted modelsContext of multimorbidityNon-Hispanic white respondentsNon-Hispanic White older adultsWhite older adultsRacial/EthnicMultimorbidity combinationsRisk factorsDiscrete-time survival modelsHigh prevalenceHigher oddsMultimorbidityWhite adultsDementiaMiddle AgedLater lifeAdultsSignificant differencesRiskLATENT CLASSES OF MULTIMORBIDITY AND ASSOCIATED CARE-RECEIVING CHARACTERISTICS FOR US OLDER ADULTS
Liu M, Nagel C, Chen S, Kaye J, Allore H, Quiñones A. LATENT CLASSES OF MULTIMORBIDITY AND ASSOCIATED CARE-RECEIVING CHARACTERISTICS FOR US OLDER ADULTS. Innovation In Aging 2023, 7: 823-823. PMCID: PMC10739216, DOI: 10.1093/geroni/igad104.2654.Peer-Reviewed Original ResearchOlder adultsCare needsMore unmet needsDifferent care needsType of careAging Trends StudyMultimorbidity combinationsMultimorbidity patternsMusculoskeletal conditionsChronic conditionsNational HealthMedian numberUnmet needAssociated careMultimorbidityCareIADL domainsLatent classesAbstract Older adultsAdultsFurther investigationFour-class solutionHealthy classCaregiversSmall proportion
2022
SOCIAL SUPPORT AND STRAIN AS PREDICTORS OF MULTIMORBIDITY FOLLOWING A MARITAL TRANSITION
Denning E, Newsom J, Botoseneanu A, Allore H, Nagel C, Dorr D, Quiñones A. SOCIAL SUPPORT AND STRAIN AS PREDICTORS OF MULTIMORBIDITY FOLLOWING A MARITAL TRANSITION. Innovation In Aging 2022, 6: 567-567. PMCID: PMC9770881, DOI: 10.1093/geroni/igac059.2136.Peer-Reviewed Original ResearchMore chronic conditionsChronic conditionsPredictors of multimorbiditySocial supportAdults age 50Race/ethnicityAge 50Multimorbidity trajectoriesOlder adultsMarital transitionsHealth declineSocial strainStressful eventsRetirement StudyChildrenSpousal supportGrowth curve modelingPiecewise growth curve modelingHealthLtParticipantsMultimorbidityMENTAL-SOMATIC MULTIMORBIDITY IN GROUP-BASED TRAJECTORIES OF COGNITIVE FUNCTION FOR MIDDLE-AGED AND OLDER ADULTS
Chen S, Nagel C, Botoseneanu A, Allore H, Newsom J, Thielke S, Kaye J, Quiñones A. MENTAL-SOMATIC MULTIMORBIDITY IN GROUP-BASED TRAJECTORIES OF COGNITIVE FUNCTION FOR MIDDLE-AGED AND OLDER ADULTS. Innovation In Aging 2022, 6: 610-610. PMCID: PMC9770737, DOI: 10.1093/geroni/igac059.2273.Peer-Reviewed Original ResearchLow baseline riskMultimorbidity combinationsBaseline riskCognitive impairmentSomatic multimorbidityHigher oddsHigher baseline riskCognitive impairment riskCognitive performanceGroup-based trajectory modelingRisk modificationSubsequent riskMultimorbiditySociodemographic factorsMental multimorbidityCognitive declineCognitive functionMiddle AgedOlder adultsImpairment riskImpairmentTrajectory class membershipRiskStrokeRetirement StudyMULTIMORBIDITY PROGRESSION AMONG MEDICARE BENEFICIARIES IN THE HEALTH AND RETIREMENT STUDY (1991–2015)
Quiñones A, Markwardt S, Bobo M, Allore H, Newsom J, Nagel C, Botoseneanu A, Dorr D. MULTIMORBIDITY PROGRESSION AMONG MEDICARE BENEFICIARIES IN THE HEALTH AND RETIREMENT STUDY (1991–2015). Innovation In Aging 2022, 6: 693-693. DOI: 10.1093/geroni/igac059.2540.Peer-Reviewed Original ResearchMultimorbidity groupObese body mass indexOlder adultsLevel of multimorbidityBody mass indexHigh incidence rateHigh multimorbidityMass indexIncidence rateED ratesMultimorbidityMedicare beneficiariesMedicare feeBirth cohortService beneficiariesLower multimorbidityFunctional lossGreater riskSociodemographic differencesDisease accumulationLater lifeAbstract Older adultsRetirement StudyHigher proportionAdultsDepressive Multimorbidity and Trajectories of Functional Status among Older Americans: Differences by Racial/Ethnic Group
Botoseneanu A, Elman M, Allore H, Dorr D, Newsom J, Nagel C, Quiñones A. Depressive Multimorbidity and Trajectories of Functional Status among Older Americans: Differences by Racial/Ethnic Group. Journal Of The American Medical Directors Association 2022, 24: 250-257.e3. PMID: 36535384, PMCID: PMC10280885, DOI: 10.1016/j.jamda.2022.11.015.Peer-Reviewed Original ResearchConceptsFunctional limitationsOlder adultsSomatic multimorbidityBody mass indexScreening/treatmentDaily living limitationsUS older adultsNon-Hispanic blacksHigher depressive symptomsAdults age 65Race/ethnicityMass indexTreatment optionsBaseline ageFunctional statusRepresentative sampleHigh prevalenceInstrumental activitiesFunctional declineDaily livingMultimorbidityDepressive symptomsSomatic diseasesDepressive symptomatologyEthnic groups
2021
Racial and Ethnic Differences in Multimorbidity Changes Over Time
Quiñones AR, Newsom JT, Elman MR, Markwardt S, Nagel CL, Dorr DA, Allore HG, Botoseneanu A. Racial and Ethnic Differences in Multimorbidity Changes Over Time. Medical Care 2021, 59: 402-409. PMID: 33821829, PMCID: PMC8024615, DOI: 10.1097/mlr.0000000000001527.Peer-Reviewed Original ResearchConceptsMinimal diseaseOlder adultsProspective cohort studyHigher depressive symptomsMultimorbidity combinationsEthnic older adultsCohort studyMultimorbidity patternsLung diseaseHeart diseaseRetirement Study respondentsDelay progressionDepressive symptomsMultimorbidityDiseaseLatent class analysisLatent classesEthnic differencesWhite AmericansStudy respondentsMultinomial logistic modelAdultsClass analysisLogistic modelParticipants
2020
An Agenda for Addressing Multimorbidity and Racial and Ethnic Disparities in Alzheimer’s Disease and Related Dementia
Quiñones AR, Kaye J, Allore HG, Botoseneanu A, Thielke SM. An Agenda for Addressing Multimorbidity and Racial and Ethnic Disparities in Alzheimer’s Disease and Related Dementia. American Journal Of Alzheimer's Disease & Other Dementias® 2020, 35: 1533317520960874. PMID: 32969234, PMCID: PMC7984095, DOI: 10.1177/1533317520960874.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseEthnic disparitiesMultiple chronic diseasesMultimorbidity combinationsPoor outcomeAdverse outcomesChronic diseasesHigh burdenRelated dementiaClinical treatmentDiseaseADRDU.S. populationDementia researchMultimorbidityOutcomesBurdenRiskBroad effectsPopulationDementiaDisparitiesCareCaregivers