2010
d-Cycloserine Reduces the Context Specificity of Pavlovian Extinction of Cocaine Cues through Actions in the Nucleus Accumbens
Torregrossa MM, Sanchez H, Taylor JR. d-Cycloserine Reduces the Context Specificity of Pavlovian Extinction of Cocaine Cues through Actions in the Nucleus Accumbens. Journal Of Neuroscience 2010, 30: 10526-10533. PMID: 20685995, PMCID: PMC2918879, DOI: 10.1523/jneurosci.2523-10.2010.Peer-Reviewed Original ResearchConceptsCue-induced reinstatementD-cycloserineNovel contextExtinction learningExtinction therapyContext specificityExtinction sessionsBrief memory reactivation sessionAdministration of DCSMemory reactivation sessionCue exposure therapyCue-induced relapseDrug-associated cuesDrug-taking contextCocaine-associated cuesAbsence of extinctionNeurobiology of addictionSelf-administer cocainePrelimbic prefrontal cortexReactivation sessionContext AContext BPavlovian extinctionExposure therapyMotivational impact
2007
Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine
Taylor JR, Lynch WJ, Sanchez H, Olausson P, Nestler EJ, Bibb JA. Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 4147-4152. PMID: 17360491, PMCID: PMC1820723, DOI: 10.1073/pnas.0610288104.Peer-Reviewed Original ResearchConceptsNucleus accumbensInhibition of Cdk5Progressive ratio scheduleStriatal dopamineLocomotor sensitizationCocaine exposureIncentive motivational effectsCocaine-induced locomotor sensitizationChronic cocaine exposureSaline-injected ratsSubsequent cocaine challengeRatio scheduleTranscription factor DeltaFosBCdk5 inhibitor roscovitineCyclin-dependent kinase 5Intra-NAc infusionsLong-term adaptationNAC infusionStriatal neuronsCocaine challengeCocaine injectionStimulant actionCocaine sensitizationLocomotor responseInfusion