2010
d-Cycloserine Reduces the Context Specificity of Pavlovian Extinction of Cocaine Cues through Actions in the Nucleus Accumbens
Torregrossa MM, Sanchez H, Taylor JR. d-Cycloserine Reduces the Context Specificity of Pavlovian Extinction of Cocaine Cues through Actions in the Nucleus Accumbens. Journal Of Neuroscience 2010, 30: 10526-10533. PMID: 20685995, PMCID: PMC2918879, DOI: 10.1523/jneurosci.2523-10.2010.Peer-Reviewed Original ResearchConceptsCue-induced reinstatementD-cycloserineNovel contextExtinction learningExtinction therapyContext specificityExtinction sessionsBrief memory reactivation sessionAdministration of DCSMemory reactivation sessionCue exposure therapyCue-induced relapseDrug-associated cuesDrug-taking contextCocaine-associated cuesAbsence of extinctionNeurobiology of addictionSelf-administer cocainePrelimbic prefrontal cortexReactivation sessionContext AContext BPavlovian extinctionExposure therapyMotivational impactReconsolidation of a Cocaine-Associated Stimulus Requires Amygdalar Protein Kinase A
Sanchez H, Quinn JJ, Torregrossa MM, Taylor JR. Reconsolidation of a Cocaine-Associated Stimulus Requires Amygdalar Protein Kinase A. Journal Of Neuroscience 2010, 30: 4401-4407. PMID: 20335476, PMCID: PMC2881637, DOI: 10.1523/jneurosci.3149-09.2010.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnalysis of VarianceAnimalsAssociation LearningCocaineConditioning, OperantCuesCyclic AMPCyclic AMP-Dependent Protein KinasesDopamine Uptake InhibitorsExploratory BehaviorExtinction, PsychologicalMaleProtein Kinase InhibitorsRatsRats, Sprague-DawleyReinforcement, PsychologySelf AdministrationThionucleotidesConceptsSubsequent cue-induced reinstatementCocaine-paired stimulusCue-induced reinstatementLight/tone stimulusIntra-amygdalar infusionLight/toneDrug-paired stimuliNew instrumental responseDrug-associated stimuliIntravenous cocaine infusionsCocaine-induced reinstatementLever extinctionMemory reconsolidationStimulus memoryMemory restabilizationReinstatement testingBehavioral treatmentPKA inhibitor Rp-cAMPSAddictive disordersTone stimuliReconsolidationInstrumental responseCocaine infusionsDrug addictionReinstatement
2005
Neonatal isolation alters the estrous cycle interactions on the acute behavioral effects of cocaine
Kosten T, Sanchez H, Jatlow P, Kehoe P. Neonatal isolation alters the estrous cycle interactions on the acute behavioral effects of cocaine. Psychoneuroendocrinology 2005, 30: 753-761. PMID: 15919581, DOI: 10.1016/j.psyneuen.2005.03.004.Peer-Reviewed Original ResearchConceptsEstrous stageNeonatal isolationBehavioral effectsNH femalesCocaine dosesNon-handled conditionsLow cocaine dosesCocaine plasma levelsEffects of estrogenVentral striatal dopamineAcute behavioral effectsAbility of cocaineHigher cocaine dosesAcquisition of cocaineAcute behavioral responsesMonoamine levelsStriatal dopamineSerotonin levelsPlasma levelsEstrous cyclicityFemale ratsISO ratsIsolation altersDiestrus stageEstrus rats
2004
Neonatal isolation enhances acquisition of cocaine self-administration and food responding in female rats
Kosten T, Sanchez H, Zhang X, Kehoe P. Neonatal isolation enhances acquisition of cocaine self-administration and food responding in female rats. Behavioural Brain Research 2004, 151: 137-149. PMID: 15084429, DOI: 10.1016/j.bbr.2003.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAnimals, NewbornBehavior, AddictiveBody WeightCocaineConditioning, OperantDopamine Uptake InhibitorsDose-Response Relationship, DrugFeeding BehaviorFemaleMaleMotor ActivityRatsRats, Sprague-DawleyReinforcement ScheduleReinforcement, PsychologySelf AdministrationSex FactorsSocial Isolation