Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine
Taylor JR, Lynch WJ, Sanchez H, Olausson P, Nestler EJ, Bibb JA. Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 4147-4152. PMID: 17360491, PMCID: PMC1820723, DOI: 10.1073/pnas.0610288104.Peer-Reviewed Original ResearchConceptsNucleus accumbensInhibition of Cdk5Progressive ratio scheduleStriatal dopamineLocomotor sensitizationCocaine exposureIncentive motivational effectsCocaine-induced locomotor sensitizationChronic cocaine exposureSaline-injected ratsSubsequent cocaine challengeRatio scheduleTranscription factor DeltaFosBCdk5 inhibitor roscovitineCyclin-dependent kinase 5Intra-NAc infusionsLong-term adaptationNAC infusionStriatal neuronsCocaine challengeCocaine injectionStimulant actionCocaine sensitizationLocomotor responseInfusion