2016
The Naturally Occurring Compound Garcinia Indica Selectively Impairs the Reconsolidation of a Cocaine-Associated Memory
Monsey MS, Sanchez H, Taylor JR. The Naturally Occurring Compound Garcinia Indica Selectively Impairs the Reconsolidation of a Cocaine-Associated Memory. Neuropsychopharmacology 2016, 42: 587-597. PMID: 27380937, PMCID: PMC5240167, DOI: 10.1038/npp.2016.117.Peer-Reviewed Original ResearchConceptsCocaine-cue memoriesCocaine self-administration trainingLight/tone cuesCue-induced cocaine-seeking behaviorCocaine-Associated MemorySelf-administration trainingCocaine-seeking behaviorActive lever pressesCue memoryInfusion of cocaineLever extinctionReconsolidation processTone cuesSuch cuesDrug takingMemoryLever pressesCuesReconsolidationNew responsesAbstinenceDrug abuseEnvironmental stimuliCocaine useCocaine access
2014
Activation of Exchange Protein Activated by cAMP in the Rat Basolateral Amygdala Impairs Reconsolidation of a Memory Associated with Self-Administered Cocaine
Wan X, Torregrossa MM, Sanchez H, Nairn AC, Taylor JR. Activation of Exchange Protein Activated by cAMP in the Rat Basolateral Amygdala Impairs Reconsolidation of a Memory Associated with Self-Administered Cocaine. PLOS ONE 2014, 9: e107359. PMID: 25259911, PMCID: PMC4178027, DOI: 10.1371/journal.pone.0107359.Peer-Reviewed Original Research
2010
d-Cycloserine Reduces the Context Specificity of Pavlovian Extinction of Cocaine Cues through Actions in the Nucleus Accumbens
Torregrossa MM, Sanchez H, Taylor JR. d-Cycloserine Reduces the Context Specificity of Pavlovian Extinction of Cocaine Cues through Actions in the Nucleus Accumbens. Journal Of Neuroscience 2010, 30: 10526-10533. PMID: 20685995, PMCID: PMC2918879, DOI: 10.1523/jneurosci.2523-10.2010.Peer-Reviewed Original ResearchConceptsCue-induced reinstatementD-cycloserineNovel contextExtinction learningExtinction therapyContext specificityExtinction sessionsBrief memory reactivation sessionAdministration of DCSMemory reactivation sessionCue exposure therapyCue-induced relapseDrug-associated cuesDrug-taking contextCocaine-associated cuesAbsence of extinctionNeurobiology of addictionSelf-administer cocainePrelimbic prefrontal cortexReactivation sessionContext AContext BPavlovian extinctionExposure therapyMotivational impactReconsolidation of a Cocaine-Associated Stimulus Requires Amygdalar Protein Kinase A
Sanchez H, Quinn JJ, Torregrossa MM, Taylor JR. Reconsolidation of a Cocaine-Associated Stimulus Requires Amygdalar Protein Kinase A. Journal Of Neuroscience 2010, 30: 4401-4407. PMID: 20335476, PMCID: PMC2881637, DOI: 10.1523/jneurosci.3149-09.2010.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnalysis of VarianceAnimalsAssociation LearningCocaineConditioning, OperantCuesCyclic AMPCyclic AMP-Dependent Protein KinasesDopamine Uptake InhibitorsExploratory BehaviorExtinction, PsychologicalMaleProtein Kinase InhibitorsRatsRats, Sprague-DawleyReinforcement, PsychologySelf AdministrationThionucleotidesConceptsSubsequent cue-induced reinstatementCocaine-paired stimulusCue-induced reinstatementLight/tone stimulusIntra-amygdalar infusionLight/toneDrug-paired stimuliNew instrumental responseDrug-associated stimuliIntravenous cocaine infusionsCocaine-induced reinstatementLever extinctionMemory reconsolidationStimulus memoryMemory restabilizationReinstatement testingBehavioral treatmentPKA inhibitor Rp-cAMPSAddictive disordersTone stimuliReconsolidationInstrumental responseCocaine infusionsDrug addictionReinstatement