2016
The Naturally Occurring Compound Garcinia Indica Selectively Impairs the Reconsolidation of a Cocaine-Associated Memory
Monsey MS, Sanchez H, Taylor JR. The Naturally Occurring Compound Garcinia Indica Selectively Impairs the Reconsolidation of a Cocaine-Associated Memory. Neuropsychopharmacology 2016, 42: 587-597. PMID: 27380937, PMCID: PMC5240167, DOI: 10.1038/npp.2016.117.Peer-Reviewed Original ResearchConceptsCocaine-cue memoriesCocaine self-administration trainingLight/tone cuesCue-induced cocaine-seeking behaviorCocaine-Associated MemorySelf-administration trainingCocaine-seeking behaviorActive lever pressesCue memoryInfusion of cocaineLever extinctionReconsolidation processTone cuesSuch cuesDrug takingMemoryLever pressesCuesReconsolidationNew responsesAbstinenceDrug abuseEnvironmental stimuliCocaine useCocaine access
2004
Neonatal isolation enhances maintenance but not reinstatement of cocaine self-administration in adult male rats
Zhang X, Sanchez H, Kehoe P, Kosten T. Neonatal isolation enhances maintenance but not reinstatement of cocaine self-administration in adult male rats. Psychopharmacology 2004, 177: 391-399. PMID: 15258719, DOI: 10.1007/s00213-004-1963-y.Peer-Reviewed Original ResearchConceptsAdult male ratsNeonatal isolationMale ratsCocaine-induced reinstatementPR scheduleCocaine dosesExtinguished self-administration behaviorLow cocaine dosesProgressive ratioEarly life stressNon-handled ratsSelf-administration behaviorAcquisition of cocaineDifferent cocaine dosesCocaine-seeking behaviorSelf-administer cocaineReinstatement of cocaineLow dosesRatsCocaineMore cocaineDosesLife stressGroup differencesSeparate groups