2014
Activation of Exchange Protein Activated by cAMP in the Rat Basolateral Amygdala Impairs Reconsolidation of a Memory Associated with Self-Administered Cocaine
Wan X, Torregrossa MM, Sanchez H, Nairn AC, Taylor JR. Activation of Exchange Protein Activated by cAMP in the Rat Basolateral Amygdala Impairs Reconsolidation of a Memory Associated with Self-Administered Cocaine. PLOS ONE 2014, 9: e107359. PMID: 25259911, PMCID: PMC4178027, DOI: 10.1371/journal.pone.0107359.Peer-Reviewed Original Research
2010
Reconsolidation of a Cocaine-Associated Stimulus Requires Amygdalar Protein Kinase A
Sanchez H, Quinn JJ, Torregrossa MM, Taylor JR. Reconsolidation of a Cocaine-Associated Stimulus Requires Amygdalar Protein Kinase A. Journal Of Neuroscience 2010, 30: 4401-4407. PMID: 20335476, PMCID: PMC2881637, DOI: 10.1523/jneurosci.3149-09.2010.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnalysis of VarianceAnimalsAssociation LearningCocaineConditioning, OperantCuesCyclic AMPCyclic AMP-Dependent Protein KinasesDopamine Uptake InhibitorsExploratory BehaviorExtinction, PsychologicalMaleProtein Kinase InhibitorsRatsRats, Sprague-DawleyReinforcement, PsychologySelf AdministrationThionucleotidesConceptsSubsequent cue-induced reinstatementCocaine-paired stimulusCue-induced reinstatementLight/tone stimulusIntra-amygdalar infusionLight/toneDrug-paired stimuliNew instrumental responseDrug-associated stimuliIntravenous cocaine infusionsCocaine-induced reinstatementLever extinctionMemory reconsolidationStimulus memoryMemory restabilizationReinstatement testingBehavioral treatmentPKA inhibitor Rp-cAMPSAddictive disordersTone stimuliReconsolidationInstrumental responseCocaine infusionsDrug addictionReinstatement
2007
Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine
Taylor JR, Lynch WJ, Sanchez H, Olausson P, Nestler EJ, Bibb JA. Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 4147-4152. PMID: 17360491, PMCID: PMC1820723, DOI: 10.1073/pnas.0610288104.Peer-Reviewed Original ResearchConceptsNucleus accumbensInhibition of Cdk5Progressive ratio scheduleStriatal dopamineLocomotor sensitizationCocaine exposureIncentive motivational effectsCocaine-induced locomotor sensitizationChronic cocaine exposureSaline-injected ratsSubsequent cocaine challengeRatio scheduleTranscription factor DeltaFosBCdk5 inhibitor roscovitineCyclin-dependent kinase 5Intra-NAc infusionsLong-term adaptationNAC infusionStriatal neuronsCocaine challengeCocaine injectionStimulant actionCocaine sensitizationLocomotor responseInfusion
2004
Neonatal isolation enhances maintenance but not reinstatement of cocaine self-administration in adult male rats
Zhang X, Sanchez H, Kehoe P, Kosten T. Neonatal isolation enhances maintenance but not reinstatement of cocaine self-administration in adult male rats. Psychopharmacology 2004, 177: 391-399. PMID: 15258719, DOI: 10.1007/s00213-004-1963-y.Peer-Reviewed Original ResearchConceptsAdult male ratsNeonatal isolationMale ratsCocaine-induced reinstatementPR scheduleCocaine dosesExtinguished self-administration behaviorLow cocaine dosesProgressive ratioEarly life stressNon-handled ratsSelf-administration behaviorAcquisition of cocaineDifferent cocaine dosesCocaine-seeking behaviorSelf-administer cocaineReinstatement of cocaineLow dosesRatsCocaineMore cocaineDosesLife stressGroup differencesSeparate groupsNeonatal isolation enhances acquisition of cocaine self-administration and food responding in female rats
Kosten T, Sanchez H, Zhang X, Kehoe P. Neonatal isolation enhances acquisition of cocaine self-administration and food responding in female rats. Behavioural Brain Research 2004, 151: 137-149. PMID: 15084429, DOI: 10.1016/j.bbr.2003.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAnimals, NewbornBehavior, AddictiveBody WeightCocaineConditioning, OperantDopamine Uptake InhibitorsDose-Response Relationship, DrugFeeding BehaviorFemaleMaleMotor ActivityRatsRats, Sprague-DawleyReinforcement ScheduleReinforcement, PsychologySelf AdministrationSex FactorsSocial Isolation