2007
Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine
Taylor JR, Lynch WJ, Sanchez H, Olausson P, Nestler EJ, Bibb JA. Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 4147-4152. PMID: 17360491, PMCID: PMC1820723, DOI: 10.1073/pnas.0610288104.Peer-Reviewed Original ResearchConceptsNucleus accumbensInhibition of Cdk5Progressive ratio scheduleStriatal dopamineLocomotor sensitizationCocaine exposureIncentive motivational effectsCocaine-induced locomotor sensitizationChronic cocaine exposureSaline-injected ratsSubsequent cocaine challengeRatio scheduleTranscription factor DeltaFosBCdk5 inhibitor roscovitineCyclin-dependent kinase 5Intra-NAc infusionsLong-term adaptationNAC infusionStriatal neuronsCocaine challengeCocaine injectionStimulant actionCocaine sensitizationLocomotor responseInfusion
2005
Neonatal isolation alters the estrous cycle interactions on the acute behavioral effects of cocaine
Kosten T, Sanchez H, Jatlow P, Kehoe P. Neonatal isolation alters the estrous cycle interactions on the acute behavioral effects of cocaine. Psychoneuroendocrinology 2005, 30: 753-761. PMID: 15919581, DOI: 10.1016/j.psyneuen.2005.03.004.Peer-Reviewed Original ResearchConceptsEstrous stageNeonatal isolationBehavioral effectsNH femalesCocaine dosesNon-handled conditionsLow cocaine dosesCocaine plasma levelsEffects of estrogenVentral striatal dopamineAcute behavioral effectsAbility of cocaineHigher cocaine dosesAcquisition of cocaineAcute behavioral responsesMonoamine levelsStriatal dopamineSerotonin levelsPlasma levelsEstrous cyclicityFemale ratsISO ratsIsolation altersDiestrus stageEstrus rats