2010
d-Cycloserine Reduces the Context Specificity of Pavlovian Extinction of Cocaine Cues through Actions in the Nucleus Accumbens
Torregrossa MM, Sanchez H, Taylor JR. d-Cycloserine Reduces the Context Specificity of Pavlovian Extinction of Cocaine Cues through Actions in the Nucleus Accumbens. Journal Of Neuroscience 2010, 30: 10526-10533. PMID: 20685995, PMCID: PMC2918879, DOI: 10.1523/jneurosci.2523-10.2010.Peer-Reviewed Original ResearchConceptsCue-induced reinstatementD-cycloserineNovel contextExtinction learningExtinction therapyContext specificityExtinction sessionsBrief memory reactivation sessionAdministration of DCSMemory reactivation sessionCue exposure therapyCue-induced relapseDrug-associated cuesDrug-taking contextCocaine-associated cuesAbsence of extinctionNeurobiology of addictionSelf-administer cocainePrelimbic prefrontal cortexReactivation sessionContext AContext BPavlovian extinctionExposure therapyMotivational impact
2004
Neonatal isolation enhances maintenance but not reinstatement of cocaine self-administration in adult male rats
Zhang X, Sanchez H, Kehoe P, Kosten T. Neonatal isolation enhances maintenance but not reinstatement of cocaine self-administration in adult male rats. Psychopharmacology 2004, 177: 391-399. PMID: 15258719, DOI: 10.1007/s00213-004-1963-y.Peer-Reviewed Original ResearchConceptsAdult male ratsNeonatal isolationMale ratsCocaine-induced reinstatementPR scheduleCocaine dosesExtinguished self-administration behaviorLow cocaine dosesProgressive ratioEarly life stressNon-handled ratsSelf-administration behaviorAcquisition of cocaineDifferent cocaine dosesCocaine-seeking behaviorSelf-administer cocaineReinstatement of cocaineLow dosesRatsCocaineMore cocaineDosesLife stressGroup differencesSeparate groupsNeonatal isolation enhances acquisition of cocaine self-administration and food responding in female rats
Kosten T, Sanchez H, Zhang X, Kehoe P. Neonatal isolation enhances acquisition of cocaine self-administration and food responding in female rats. Behavioural Brain Research 2004, 151: 137-149. PMID: 15084429, DOI: 10.1016/j.bbr.2003.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAnimals, NewbornBehavior, AddictiveBody WeightCocaineConditioning, OperantDopamine Uptake InhibitorsDose-Response Relationship, DrugFeeding BehaviorFemaleMaleMotor ActivityRatsRats, Sprague-DawleyReinforcement ScheduleReinforcement, PsychologySelf AdministrationSex FactorsSocial Isolation