d-Cycloserine Reduces the Context Specificity of Pavlovian Extinction of Cocaine Cues through Actions in the Nucleus Accumbens
Torregrossa MM, Sanchez H, Taylor JR. d-Cycloserine Reduces the Context Specificity of Pavlovian Extinction of Cocaine Cues through Actions in the Nucleus Accumbens. Journal Of Neuroscience 2010, 30: 10526-10533. PMID: 20685995, PMCID: PMC2918879, DOI: 10.1523/jneurosci.2523-10.2010.Peer-Reviewed Original ResearchConceptsCue-induced reinstatementD-cycloserineNovel contextExtinction learningExtinction therapyContext specificityExtinction sessionsBrief memory reactivation sessionAdministration of DCSMemory reactivation sessionCue exposure therapyCue-induced relapseDrug-associated cuesDrug-taking contextCocaine-associated cuesAbsence of extinctionNeurobiology of addictionSelf-administer cocainePrelimbic prefrontal cortexReactivation sessionContext AContext BPavlovian extinctionExposure therapyMotivational impact