Neonatal isolation alters the estrous cycle interactions on the acute behavioral effects of cocaine
Kosten T, Sanchez H, Jatlow P, Kehoe P. Neonatal isolation alters the estrous cycle interactions on the acute behavioral effects of cocaine. Psychoneuroendocrinology 2005, 30: 753-761. PMID: 15919581, DOI: 10.1016/j.psyneuen.2005.03.004.Peer-Reviewed Original ResearchConceptsEstrous stageNeonatal isolationBehavioral effectsNH femalesCocaine dosesNon-handled conditionsLow cocaine dosesCocaine plasma levelsEffects of estrogenVentral striatal dopamineAcute behavioral effectsAbility of cocaineHigher cocaine dosesAcquisition of cocaineAcute behavioral responsesMonoamine levelsStriatal dopamineSerotonin levelsPlasma levelsEstrous cyclicityFemale ratsISO ratsIsolation altersDiestrus stageEstrus rats