Neonatal isolation enhances maintenance but not reinstatement of cocaine self-administration in adult male rats
Zhang X, Sanchez H, Kehoe P, Kosten T. Neonatal isolation enhances maintenance but not reinstatement of cocaine self-administration in adult male rats. Psychopharmacology 2004, 177: 391-399. PMID: 15258719, DOI: 10.1007/s00213-004-1963-y.Peer-Reviewed Original ResearchConceptsAdult male ratsNeonatal isolationMale ratsCocaine-induced reinstatementPR scheduleCocaine dosesExtinguished self-administration behaviorLow cocaine dosesProgressive ratioEarly life stressNon-handled ratsSelf-administration behaviorAcquisition of cocaineDifferent cocaine dosesCocaine-seeking behaviorSelf-administer cocaineReinstatement of cocaineLow dosesRatsCocaineMore cocaineDosesLife stressGroup differencesSeparate groups