Neonatal isolation enhances maintenance but not reinstatement of cocaine self-administration in adult male rats
Zhang X, Sanchez H, Kehoe P, Kosten T. Neonatal isolation enhances maintenance but not reinstatement of cocaine self-administration in adult male rats. Psychopharmacology 2004, 177: 391-399. PMID: 15258719, DOI: 10.1007/s00213-004-1963-y.Peer-Reviewed Original ResearchConceptsAdult male ratsNeonatal isolationMale ratsCocaine-induced reinstatementPR scheduleCocaine dosesExtinguished self-administration behaviorLow cocaine dosesProgressive ratioEarly life stressNon-handled ratsSelf-administration behaviorAcquisition of cocaineDifferent cocaine dosesCocaine-seeking behaviorSelf-administer cocaineReinstatement of cocaineLow dosesRatsCocaineMore cocaineDosesLife stressGroup differencesSeparate groupsNeonatal isolation enhances acquisition of cocaine self-administration and food responding in female rats
Kosten T, Sanchez H, Zhang X, Kehoe P. Neonatal isolation enhances acquisition of cocaine self-administration and food responding in female rats. Behavioural Brain Research 2004, 151: 137-149. PMID: 15084429, DOI: 10.1016/j.bbr.2003.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAnimals, NewbornBehavior, AddictiveBody WeightCocaineConditioning, OperantDopamine Uptake InhibitorsDose-Response Relationship, DrugFeeding BehaviorFemaleMaleMotor ActivityRatsRats, Sprague-DawleyReinforcement ScheduleReinforcement, PsychologySelf AdministrationSex FactorsSocial Isolation