2017
Placental 11 β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) expression very early during human pregnancy
Salvante KG, Milano K, Kliman HJ, Nepomnaschy PA. Placental 11 β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) expression very early during human pregnancy. Journal Of Developmental Origins Of Health And Disease 2017, 8: 149-154. PMID: 28112069, DOI: 10.1017/s2040174416000611.Peer-Reviewed Original ResearchConceptsProtective roleHydroxysteroid dehydrogenase type 2Intra-uterine growth restrictionType 2 expressionUterine endometrial glandsCritical protective roleDehydrogenase type 2Maternal-fetal exchangeHypothesized protective roleColumnar epithelial cellsGlucocorticoid exposureEndometrial glandsHuman pregnancyBirth weightGrowth restrictionCortisol exposurePlacental expressionBioactive cortisolHuman fetusesType 2Postnatal developmentPhysiologic stressEpithelial cellsImmunocytochemical analysisDevelopmental outcomes
2013
Trophoblast Inclusions Are Significantly Increased in the Placentas of Children in Families at Risk for Autism
Walker CK, Anderson KW, Milano KM, Ye S, Tancredi DJ, Pessah IN, Hertz-Picciotto I, Kliman HJ. Trophoblast Inclusions Are Significantly Increased in the Placentas of Children in Families at Risk for Autism. Biological Psychiatry 2013, 74: 204-211. PMID: 23623455, PMCID: PMC3755347, DOI: 10.1016/j.biopsych.2013.03.006.Peer-Reviewed Original ResearchConceptsElevated riskPlacentas of childrenTrophoblast inclusionsUncomplicated term pregnanciesAutism spectrum disorderPositive likelihood ratioTargeted early interventionsNeurodevelopmental compromiseMultiparous womenTerm pregnancyRisk pregnanciesBiological childrenControl placentasBehavioral symptomsEarly interventionNeurodevelopmental vulnerabilityPlacentaCritical windowRisk statusPregnancyRiskNewbornsChildrenDevelopmental outcomesControl samples