1994
Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo
Feinberg RF, Kliman HJ, Wang CL. Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo. The Journal Of Clinical Endocrinology & Metabolism 1994, 78: 1241-1248. PMID: 8175984, DOI: 10.1210/jcem.78.5.8175984.Peer-Reviewed Original ResearchConceptsTGF beta 1TGF betaBeta 1Ability of trophoblastsAnti-TGF betaSevere alloimmune thrombocytopeniaThird trimester placentasPlatelet-poor serumDose-response analysisPregnancy tissueCord serumAlloimmune thrombocytopeniaCytokine presentUterine deciduaExtracellular matrixVillous syncytiotrophoblastTrimester placentaNormal serumHuman cytotrophoblastsGrowth factor-beta stimulatesOncofetal fibronectinNormal morphological differentiationCulture secreteStimulatory responseThrombocytopenic serum
1986
Purification, Characterization, and in vitro Differentiation of Cytotrophoblasts from Human Term Placentae*
KLIMAN H, NESTLER J, SERMASI E, SANGER J, STRAUSS J. Purification, Characterization, and in vitro Differentiation of Cytotrophoblasts from Human Term Placentae*. Endocrinology 1986, 118: 1567-1582. PMID: 3512258, DOI: 10.1210/endo-118-4-1567.Peer-Reviewed Original ResearchConceptsHuman term placentaTerm placentaImmunoperoxidase methodHCG-positive cellsOccasional single cellsPregnancy-specific beta 1Human placental lactogenPercoll gradient centrifugation stepDifferentiation of cytotrophoblastsPregnancy-specific betaFunctional syncytiotrophoblastsPlacental lactogenSyncytial groupsCultured trophoblastsHuman cytotrophoblastsOccasional cellsProgesterone synthesisSyncytial trophoblastHCGEndothelial cellsBeta 1CytotrophoblastsTrophoblastTime pointsPlacenta