1997
Repeated Doses of the Perfluorocarbon FC-100 Improve Lung Function of Preterm Lambs
Moya F, Llanos A, Ríos A, Riquelme R, Moraga F, Rubio L, Salvo H, Jacobs H. Repeated Doses of the Perfluorocarbon FC-100 Improve Lung Function of Preterm Lambs. Pediatric Research 1997, 42: 893-898. PMID: 9396575, DOI: 10.1203/00006450-199712000-00028.Peer-Reviewed Original ResearchConceptsLung functionPreterm lambsInitial doseIntratracheal administrationFC-100Administration of ExosurfSurfactant-deficient animalsSynthetic surfactant ExosurfArterial blood pressureDynamic lung compliancePreterm neonatesBlood pressureLung complianceSingle doseArterial PO2Arterial PCO2Surfactant deficiencyHeart rateAdditional doseExosurfStudy periodDoseAdministrationDosesSimilar changes
1990
Effect of artificial surfactant on pulmonary function in preterm and full-term lambs
Gladstone I, Ray A, Salafia C, Perez-Fontan J, Mercurio M, Jacobs H. Effect of artificial surfactant on pulmonary function in preterm and full-term lambs. Journal Of Applied Physiology 1990, 69: 465-472. PMID: 2121700, DOI: 10.1152/jappl.1990.69.2.465.Peer-Reviewed Original ResearchConceptsFunctional residual capacityFull-term lambsMean lung volumePreterm lambsLung volumeResidual capacityTest agentsFC-100Higher minimum surface tensionsRespiratory failureLung functionPulmonary functionLung expansionAlveolar washMinimum surface tensionDynamic complianceArtificial surfactantQualitative histologyOxygenationLambsAgentsGas exchangePretermComplianceHistology
1986
Left ventricular performance and contractility before and after volume infusion: a comparative study of preterm and full-term newborn lambs.
Baylen B, Ogata H, Ikegami M, Jacobs H, Jobe A, Emmanouilides G. Left ventricular performance and contractility before and after volume infusion: a comparative study of preterm and full-term newborn lambs. Circulation 1986, 73: 1042-1049. PMID: 3754496, DOI: 10.1161/01.cir.73.5.1042.Peer-Reviewed Original ResearchConceptsFull-term lambsLeft ventricular performanceVolume infusionPreterm lambsVentricular performanceStroke workLeft ventricular peak dP/dtLeft ventricleVentricular peak dP/dtLeft ventricular end-diastolic volumeFull-term newborn lambsVentricular end-diastolic volumeLeft ventricular stroke workPeak dP/dtGreater stroke workPostnatal circulatory adaptationSystemic vascular resistanceVentricular stroke workFull-term animalsDays gestational ageEnd-diastolic volumeLeft ventricular pressureDP/dtVascular resistancePulmonary functionHemodynamic Effects of High Frequency Ventilation in Surfactant-Treated Preterm Lambs
Oguchi K, Baylen B, Ikegami M, Jacobs H, Berry D, Jobe A, Emmanouilides G. Hemodynamic Effects of High Frequency Ventilation in Surfactant-Treated Preterm Lambs. Neonatology 1986, 49: 21-28. PMID: 3753885, DOI: 10.1159/000242505.Peer-Reviewed Original ResearchConceptsHigh-frequency ventilationConventional ventilationHemodynamic effectsDuctus arteriosusPreterm lambsFrequency ventilationSame mean airway pressureLV end-diastolic volumeRight ductal shuntSurfactant-treated lambsMean airway pressureDeleterious hemodynamic effectsOrgan blood flowMin of ageEnd-diastolic volumeBlood gas valuesDays gestational ageLV stroke volumeBlood flow measurementsComparable ventilationDuctal shuntAirway pressureDuctal occlusionHemodynamic statusArterial pressure
1985
The Contractility and Performance of the Preterm Left Ventricle before and after Early Patent Ductus Arteriosus Occlusion in Surfactant- Treated Lambs
Baylen B, Ogata H, Oguchi K, Ikegami M, Jacobs H, Jobe A, Emmanouilides G. The Contractility and Performance of the Preterm Left Ventricle before and after Early Patent Ductus Arteriosus Occlusion in Surfactant- Treated Lambs. Pediatric Research 1985, 19: 1053-1058. PMID: 3840585, DOI: 10.1203/00006450-198510000-00022.Peer-Reviewed Original ResearchConceptsPatent ductus arteriosusSystemic blood flowEnd-diastolic volumeBlood flowDuctal shuntingSystemic perfusionPreterm lambsDuctus arteriosusEffective systemic blood flowVentricle end-diastolic volumeEarly hemodynamic responseLeft ventricle outputLeft-right shuntPatent ductus arteriosus occlusionLeft ventricular outputCardiac output stateLeft ventricle end-diastolic volumeOrgan blood flowDuctus arteriosus occlusionBlood flow measurementsDuctal shuntDuctal occlusionHemodynamic profileEjection fractionVentricular outputLung protein leaks in ventilated lambs: effects of gestational age
Jobe A, Jacobs H, Ikegami M, Berry D. Lung protein leaks in ventilated lambs: effects of gestational age. Journal Of Applied Physiology 1985, 58: 1246-1251. PMID: 3988678, DOI: 10.1152/jappl.1985.58.4.1246.Peer-Reviewed Original ResearchConceptsDays gestational ageGestational ageFull-term lambsGroups of lambsVentilated lambsLung tissueAlveolar washBlood gas valuesNatural sheep surfactantPremature lambsPreterm lambsPremature lungIntravascular injectionSheep surfactantLung proteinGas valuesPCO2 valuesAgeAlveoliAirwayLambsBidirectional fluxesTissueGroupAlbumin
1983
Left ventricular performance and regional blood flows before and after ductus arteriosus occlusion in premature lambs treated with surfactant.
Baylen B, Ogata H, Ikegami M, Jacobs H, Jobe A, Emmanouilides G. Left ventricular performance and regional blood flows before and after ductus arteriosus occlusion in premature lambs treated with surfactant. Circulation 1983, 67: 837-843. PMID: 6687448, DOI: 10.1161/01.cir.67.4.837.Peer-Reviewed Original ResearchConceptsPatent ductus arteriosusSystemic blood flowBlood flowVentricular performanceLV end-diastolic pressureEarly pathologic manifestationsOvert LV dysfunctionRight PDA shuntEnd-diastolic pressureHours of lifeLeft ventricular performanceRadionuclide-labeled microspheresDuctus arteriosus occlusionRegional blood flowPDA shuntLV dysfunctionPremature lambsRight shuntDuctus arteriosusEjection fractionPreterm lambsHemodynamic consequencesCardiac outputLeft ventriculographyPathologic manifestations