Chapter One Vertical Pathway Targeting in Cancer Therapy
Shahbazian D, Sznol J, Kluger HM. Chapter One Vertical Pathway Targeting in Cancer Therapy. Advances In Pharmacology 2012, 65: 1-26. PMID: 22959021, DOI: 10.1016/b978-0-12-397927-8.00001-4.Peer-Reviewed Original ResearchConceptsVital cellular processesDifferent signaling pathwaysDNA maintenanceCellular processesCell divisionDrug combinationsSignaling pathwaysSame pathwayAdaptive responseParticular mutationCell proliferationRecent discoveryPathwayTypes of cancerFragile nodesAdditional targetsGrowth inhibitoryUnavoidable toxicitiesMutationsMultitarget inhibitionCytotoxic effectsCancer researchSolid tumorsProlonged responseMalignant cells