2024
Optimizing antithrombotic therapy in patients with coexisting cardiovascular and gastrointestinal disease
Talasaz A, Sadeghipour P, Ortega-Paz L, Kakavand H, Aghakouchakzadeh M, Beavers C, Fanikos J, Eikelboom J, Siegal D, Monreal M, Jimenez D, Vaduganathan M, Castellucci L, Cuker A, Barnes G, Connors J, Secemsky E, Van Tassell B, De Caterina R, Kurlander J, Aminian A, Piazza G, Goldhaber S, Moores L, Middeldorp S, Kirtane A, Elkind M, Angiolillo D, Konstantinides S, Lip G, Stone G, Cushman M, Krumholz H, Mehran R, Bhatt D, Bikdeli B. Optimizing antithrombotic therapy in patients with coexisting cardiovascular and gastrointestinal disease. Nature Reviews Cardiology 2024, 21: 574-592. PMID: 38509244, DOI: 10.1038/s41569-024-01003-3.Peer-Reviewed Original ResearchRisk of gastrointestinal bleedingGastrointestinal bleedingAntithrombotic therapyHigh risk of gastrointestinal bleedingIncreased risk of bleedingRisk of bleedingGastrointestinal diseasesEfficacy of antithrombotic agentsAntithrombotic regimensConcomitant medicationsRisk stratificationClinical evidenceGastrointestinal comorbiditiesMultidisciplinary discussionAntithrombotic drugsAntithrombotic agentsIncreased riskHigh riskPatientsGastrointestinal disordersCardiovascular diseaseTherapyBleedingDiseaseMedical societies
2023
Sex‐Specific Associations of Obstructive Sleep Apnea Risk With Patient Characteristics and Functional Outcomes After Acute Myocardial Infarction: Evidence From the VIRGO Study
Gupta A, Barthel A, Mahajan S, Dreyer R, Yaggi H, Bueno H, Lichtman J, Krumholz H. Sex‐Specific Associations of Obstructive Sleep Apnea Risk With Patient Characteristics and Functional Outcomes After Acute Myocardial Infarction: Evidence From the VIRGO Study. Journal Of The American Heart Association 2023, 12: e027225. PMID: 37702090, PMCID: PMC10547292, DOI: 10.1161/jaha.122.027225.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaAcute myocardial infarctionHigh OSA riskOSA riskSex-specific associationsFunctional outcomeHealth statusHigh riskVIRGO StudyMyocardial infarctionDepressive symptomsHistory of OSATime of AMIImpact of OSAObstructive sleep apnea riskLow-risk patientsSleep apnea riskMajority of patientsTime of presentationSex-specific outcomesWorse health statusHigh-risk menPoor health statusMental health statusPoor health outcomesRelationship Between In-Hospital Adverse Events and Hospital Performance on 30-Day All-cause Mortality and Readmission for Patients With Heart Failure
Wang Y, Eldridge N, Metersky M, Rodrick D, Eckenrode S, Mathew J, Galusha D, Peterson A, Hunt D, Normand S, Krumholz H. Relationship Between In-Hospital Adverse Events and Hospital Performance on 30-Day All-cause Mortality and Readmission for Patients With Heart Failure. Circulation Cardiovascular Quality And Outcomes 2023, 16: e009573. PMID: 37463255, PMCID: PMC10351904, DOI: 10.1161/circoutcomes.122.009573.Peer-Reviewed Original ResearchConceptsMore adverse eventsAdverse eventsHeart failureCause mortalityReadmission ratesHigh riskMedicare Patient Safety Monitoring SystemHospital-acquired adverse eventsIn-Hospital Adverse EventsHospital adverse eventsRate of patientsPatient Safety DatabasePerformance categoriesAdverse event dataCross-sectional studyUnited States CentersHospital performanceHospital characteristicsReadmission dataPatient riskMAIN OUTCOMEPatientsWorst hospitalsHospitalHigh mortalitySex Difference in Outcomes of Acute Myocardial Infarction in Young Patients
Sawano M, Lu Y, Caraballo C, Mahajan S, Dreyer R, Lichtman J, D'Onofrio G, Spatz E, Khera R, Onuma O, Murugiah K, Spertus J, Krumholz H. Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients. Journal Of The American College Of Cardiology 2023, 81: 1797-1806. PMID: 37137590, DOI: 10.1016/j.jacc.2023.03.383.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNoncardiac hospitalizationsSubdistribution HRYounger patientsMyocardial infarctionSex differencesYoung womenCause-specific hospitalizationsCause of hospitalizationWorse health statusSignificant sex disparityNoncardiovascular hospitalizationsVIRGO StudyIndex episodeAdverse outcomesIncidence rateHospitalizationHigh riskSex disparitiesHealth statusPatientsU.S. hospitalsWomenInfarctionOutcomes
2022
Analysis of Hospital-Level Readmission Rates and Variation in Adverse Events Among Patients With Pneumonia in the United States
Wang Y, Eldridge N, Metersky ML, Rodrick D, Faniel C, Eckenrode S, Mathew J, Galusha DH, Tasimi A, Ho SY, Jaser L, Peterson A, Normand ST, Krumholz HM. Analysis of Hospital-Level Readmission Rates and Variation in Adverse Events Among Patients With Pneumonia in the United States. JAMA Network Open 2022, 5: e2214586. PMID: 35639379, PMCID: PMC9157270, DOI: 10.1001/jamanetworkopen.2022.14586.Peer-Reviewed Original ResearchConceptsRisk-standardized readmission ratesMedicare Patient Safety Monitoring SystemCause readmission rateAdverse eventsReadmission ratesHigh riskHospital-level readmission ratesHigher patient riskHospital adverse eventsAdverse event dataCross-sectional studyHospital performanceIndex hospitalizationMedian ageHospital characteristicsMedical recordsReadmission dataPatient riskHospital careMAIN OUTCOMEPneumoniaHospital levelPatientsReadmissionGreater risk
2021
Predictors of increased mortality in untreated moderate aortic stenosis
Gupta A, Liu T, Pounds C, Sharma R, Yong C, Krumholz H, Leon M. Predictors of increased mortality in untreated moderate aortic stenosis. European Heart Journal 2021, 42: ehab724.1573. DOI: 10.1093/eurheartj/ehab724.1573.Peer-Reviewed Original ResearchModerate aortic stenosisLong-term mortalityCoronary artery diseaseSeverity of ASAortic stenosisArtery diseaseAtrial fibrillationHeart failureUntreated severe aortic stenosisWorse long-term mortalityPoor long-term survivalSevere aortic stenosisAortic valve replacementHigh-risk featuresMild aortic stenosisPrognosis of patientsKaplan-Meier analysisLong-term survivalElectronic health recordsValve replacementAS severityMale sexRisk factorsSeverity groupsHigh riskPrevalence of Dyslipidemia and Availability of Lipid-Lowering Medications Among Primary Health Care Settings in China
Lu Y, Zhang H, Lu J, Ding Q, Li X, Wang X, Sun D, Tan L, Mu L, Liu J, Feng F, Yang H, Zhao H, Schulz WL, Krumholz HM, Pan X, Li J, Huang C, Dong Z, Jiang B, Guo Z, Zhang Y, Sun J, Liu Y, Ren Z, Meng Y, Wang Z, Xi Y, Xing L, Tian Y, Liu J, Fu Y, Liu T, Sun W, Yan S, Jin L, Zheng Y, Wang J, Yan J, Xu X, Chen Y, Xing X, Zhang L, Zhong W, Fang X, Zhu L, Xu Y, Guo X, Xu C, Zhou G, Fan L, Qi M, Zhu S, Qi J, Li J, Yin L, Liu Q, Geng Q, Feng Y, Wang J, Wen H, Han X, Liu P, Ding X, Xu J, Deng Y, He J, Liu G, Jiang C, Zha S, Yang C, Bai G, Yu Y, Tashi Z, Qiu L, Hu Z, He H, Zhang J, Zhou M, Li X, Zhao J, Ma S, Ma Y, Huang Y, Zhang Y, Li F, Shen J. Prevalence of Dyslipidemia and Availability of Lipid-Lowering Medications Among Primary Health Care Settings in China. JAMA Network Open 2021, 4: e2127573. PMID: 34586366, PMCID: PMC8482054, DOI: 10.1001/jamanetworkopen.2021.27573.Peer-Reviewed Original ResearchConceptsAtherosclerotic cardiovascular diseaseLipid-lowering medicationsPrimary care institutionsPrevalence of dyslipidemiaControl of dyslipidemiaLipoprotein cholesterolCare institutionsControl rateFemale sexCardiovascular diseaseMAIN OUTCOMEHigh riskNonstatin lipid-lowering drugsHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolPrimary health care settingsMajor public health problemLipid lowering medicationsMillion Persons ProjectOverall control rateLDL-C levelsLipid-lowering drugsCross-sectional studyPublic health problemHealth care settingsObesity Prevalence and Risks Among Chinese Adults
Mu L, Liu J, Zhou G, Wu C, Chen B, Lu Y, Lu J, Yan X, Zhu Z, Nasir K, Spatz ES, Krumholz HM, Zheng X. Obesity Prevalence and Risks Among Chinese Adults. Circulation Cardiovascular Quality And Outcomes 2021, 14: e007292. PMID: 34107739, PMCID: PMC8204767, DOI: 10.1161/circoutcomes.120.007292.Peer-Reviewed Original ResearchConceptsAbdominal obesitySocio-demographic subgroupsSocio-demographic associationsOverall obesityHigh riskMillion Persons ProjectEpidemic of obesityAge-standardized ratesCommunity-dwelling adultsAssociation of ageMultivariable mixed modelsObesity prevalenceOlder womenLower riskObesityOlder menChinese adultsPrevalenceWomenRiskMenPersons ProjectSubgroupsAssociationAdults
2020
Obesity prevalence and risks among Chinese adults: findings from China PEACE Million Persons Project, 2014–2018
Mu L, Liu J, Zhou G, Wu C, Chen B, Lu Y, Lu J, Yan X, Zhu Z, Nasir K, Spatz E, Krumholz H, Zheng X. Obesity prevalence and risks among Chinese adults: findings from China PEACE Million Persons Project, 2014–2018. European Heart Journal 2020, 41: ehaa946.3034. DOI: 10.1093/ehjci/ehaa946.3034.Peer-Reviewed Original ResearchAbdominal obesityOverall obesityLargest age groupHigh riskSocio-demographic characteristicsSocio-demographic subgroupsEffective policy interventionsLower riskAge groupsMillion Persons ProjectContemporary ChinaCAMS Innovation FundAssociation of ageMultivariable mixed modelsPolicy interventionsCommunity-dwelling participantsMagnitude of associationPolicy implicationsHigher educationCurrent smokingNormal weightObese individualsObesity prevalenceSocio-demographic variablesHigh prevalenceAssociation Between Subsequent Hospitalizations and Recurrent Acute Myocardial Infarction Within 1 Year After Acute Myocardial Infarction
Wang Y, Leifheit E, Normand S, Krumholz HM. Association Between Subsequent Hospitalizations and Recurrent Acute Myocardial Infarction Within 1 Year After Acute Myocardial Infarction. Journal Of The American Heart Association 2020, 9: e014907. PMID: 32172654, PMCID: PMC7335517, DOI: 10.1161/jaha.119.014907.Peer-Reviewed Original ResearchConceptsRecurrent acute myocardial infarctionAcute myocardial infarctionIndex acute myocardial infarctionClinical Classification SoftwareMyocardial infarctionDisease categoriesRisk of deathCox regression modelPost-acute careAcute care hospitalsOccurrence of hospitalizationLow recurrence riskUnplanned rehospitalizationSubsequent hospitalizationBackground PatientsHazard ratioPatient characteristicsSecondary preventionMedian timeService patientsChronic diseasesPatient riskOutcome measuresRehospitalizationHigh risk
2019
Variation and Disparities in Awareness of Myocardial Infarction Symptoms Among Adults in the United States
Mahajan S, Valero-Elizondo J, Khera R, Desai NR, Blankstein R, Blaha MJ, Virani SS, Kash BA, Zoghbi WA, Krumholz HM, Nasir K. Variation and Disparities in Awareness of Myocardial Infarction Symptoms Among Adults in the United States. JAMA Network Open 2019, 2: e1917885. PMID: 31851350, PMCID: PMC6991230, DOI: 10.1001/jamanetworkopen.2019.17885.Peer-Reviewed Original ResearchConceptsMyocardial infarction symptomsShortness of breathMyocardial infarctionInfarction symptomsLow education levelEmergency medical servicesChest painSociodemographic subgroupsNational Health Interview SurveyEmergency cardiac careCross-sectional studyMedical servicesHealth Interview SurveyPublic health initiativesEducation levelLow-income subgroupsPrompt recognitionBack painCommon symptomsMale sexCardiac careHigher oddsHispanic ethnicityMAIN OUTCOMEHigh riskCharacteristics of High Cardiovascular Risk in 1.7 Million Chinese Adults.
Lu J, Lu Y, Yang H, Bilige W, Li Y, Schulz W, Masoudi FA, Krumholz HM. Characteristics of High Cardiovascular Risk in 1.7 Million Chinese Adults. Annals Of Internal Medicine 2019, 170: 298-308. PMID: 30776800, DOI: 10.7326/m18-1932.Peer-Reviewed Original ResearchConceptsHigh CVD riskCVD riskHigh riskHigh cardiovascular disease riskCardiovascular risk increasesHigh cardiovascular riskOverall study populationCardiovascular disease riskBody mass indexMultivariable mixed modelsNational Health CommissionAntihypertensive medicationsAspirin useCardiovascular riskCVD screeningMass indexStudy populationChinese adultsHan ethnicityDisease riskStatinsMixed modelsHealth CommissionSocioeconomic statusPopulation subgroupsEducation level and outcomes after acute myocardial infarction in China
Huo X, Khera R, Zhang L, Herrin J, Bai X, Wang Q, Lu Y, Nasir K, Hu S, Li J, Li X, Zheng X, Masoudi FA, Spertus JA, Krumholz HM, Jiang L. Education level and outcomes after acute myocardial infarction in China. Heart 2019, 105: 946. PMID: 30661037, PMCID: PMC6582708, DOI: 10.1136/heartjnl-2018-313752.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsLow educational attainmentAcute myocardial infarction (AMI) outcomesAdverse cardiovascular eventsFuture healthcare interventionsMyocardial infarction outcomesCardiovascular risk factorsRisk-adjusted analysisAcute myocardial infarctionMedian participant ageCardiovascular eventsCause mortalityAdverse eventsConsecutive patientsAMI outcomesChina PatientUnadjusted analysesMyocardial infarctionRisk factorsChinese cohortHigh riskEducational attainmentEducational attainment groupsHealthcare interventionsPatients
2018
Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies
Pennells L, Kaptoge S, Wood A, Sweeting M, Zhao X, White I, Burgess S, Willeit P, Bolton T, Moons KGM, van der Schouw YT, Selmer R, Khaw KT, Gudnason V, Assmann G, Amouyel P, Salomaa V, Kivimaki M, Nordestgaard BG, Blaha MJ, Kuller LH, Brenner H, Gillum RF, Meisinger C, Ford I, Knuiman MW, Rosengren A, Lawlor DA, Völzke H, Cooper C, Ibañez A, Casiglia E, Kauhanen J, Cooper JA, Rodriguez B, Sundström J, Barrett-Connor E, Dankner R, Nietert PJ, Davidson KW, Wallace RB, Blazer DG, Björkelund C, Donfrancesco C, Krumholz HM, Nissinen A, Davis BR, Coady S, Whincup PH, Jørgensen T, Ducimetiere P, Trevisan M, Engström G, Crespo CJ, Meade TW, Visser M, Kromhout D, Kiechl S, Daimon M, Price JF, de la Cámara A, Jukema J, Lamarche B, Onat A, Simons LA, Kavousi M, Ben-Shlomo Y, Gallacher J, Dekker JM, Arima H, Shara N, Tipping RW, Roussel R, Brunner EJ, Koenig W, Sakurai M, Pavlovic J, Gansevoort RT, Nagel D, Goldbourt U, Barr ELM, Palmieri L, Njølstad I, Sato S, Verschuren W, Varghese CV, Graham I, Onuma O, Greenland P, Woodward M, Ezzati M, Psaty BM, Sattar N, Jackson R, Ridker PM, Cook NR, D'Agostino RB, Thompson SG, Danesh J, Di Angelantonio E, Tipping R, Simpson L, Pressel S, Couper D, Nambi V, Matsushita K, Folsom A, Shaw J, Magliano D, Zimmet P, Knuiman M, Whincup P, Wannamethee S, Willeit J, Santer P, Egger G, Casas J, Amuzu A, Ben-Shlomo Y, Gallacher J, Tikhonoff V, Casiglia E, Sutherland S, Nietert P, Cushman M, Psaty B, Søgaard A, Håheim L, Ariansen I, Tybjærg-Hansen A, Jensen G, Schnohr P, Giampaoli S, Vanuzzo D, Panico S, Palmieri L, Balkau B, Bonnet F, Marre M, de la Cámara A, Herrera M, Friedlander Y, McCallum J, McLachlan S, Guralnik J, Phillips C, Guralnik J, Guralnik J, Guralnik J, Khaw K, Wareham N, Schöttker B, Saum K, Holleczek B, Nissinen A, Tolonen H, Giampaoli S, Donfrancesco C, Vartiainen E, Jousilahti P, Harald K, D’Agostino R, Massaro J, Pencina M, Vasan R, D’Agostino R, Massaro J, Pencina M, Vasan R, Kayama T, Kato T, Oizumi T, Jespersen J, Møller L, Bladbjerg E, Chetrit A, Rosengren A, Wilhelmsen L, Björkelund C, Lissner L, Nagel D, Dennison E, Kiyohara Y, Ninomiya T, Doi Y, Rodriguez B, Nijpels G, Stehouwer C, Sato S, Kazumasa Y, Iso H, Goldbourt U, Salomaa V, Vartiainen E, Kurl S, Tuomainen T, Salonen J, Visser M, Deeg D, Meade T, Nilsson P, Hedblad B, Melander O, De Boer I, DeFilippis A, Verschuren W, Sattar N, Watt G, Meisinger C, Koenig W, Koenig W, Meisinger C, Verschuren W, Rosengren A, Kuller L, Tverdal A, Gillum R, Cooper J, Kirkland S, Shimbo D, Shaffer J, Sato S, Kazumasa Y, Iso H, Ducimetiere P, Bakker S, van der Harst P, Hillege H, Crespo C, Amouyel P, Dallongeville J, Assmann G, Schulte H, Trompet S, Smit R, Stott D, van der Schouw Y, Després J, Cantin B, Dagenais G, Laughlin G, Wingard D, Khaw K, Trevisan M, Aspelund T, Eiriksdottir G, Gudmundsson E, Ikram A, van Rooij F, Franco O, Rueda-Ochoa O, Muka T, Glisic M, Tunstall-Pedoe H, Völzke H, Howard B, Zhang Y, Jolly S, Gallacher J, Davey-Smith G, Can G, Yüksel H, Nakagawa H, Morikawa Y, Miura K, Njølstad I, Ingelsson M, Giedraitis V, Ridker P, Gaziano J, Kivimaki M, Shipley M, Brunner E, Shipley M, Arndt V, Brenner H, Cook N, Ridker P, Ford I, Sattar N, Ibañez A, Geleijnse J. Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies. European Heart Journal 2018, 40: 621-631. PMID: 30476079, PMCID: PMC6374687, DOI: 10.1093/eurheartj/ehy653.Peer-Reviewed Original ResearchConceptsSystematic Coronary Risk EvaluationReynolds Risk ScoreFramingham risk scoreRisk algorithmStatin therapyCVD riskProspective studyRisk discriminationRisk scoreCardiovascular disease risk estimationPrimary prevention guidelinesCoronary Risk EvaluationRisk factor profileYear CVD riskCardiovascular risk algorithmsCVD risk algorithmsIndividual participant dataDisease risk estimationCohort EquationsCVD eventsCVD incidencePrevention guidelinesHigh riskFactor profileHead comparisonRisk Factors Associated With Major Cardiovascular Events 1 Year After Acute Myocardial Infarction
Wang Y, Li J, Zheng X, Jiang Z, Hu S, Wadhera RK, Bai X, Lu J, Wang Q, Li Y, Wu C, Xing C, Normand SL, Krumholz HM, Jiang L. Risk Factors Associated With Major Cardiovascular Events 1 Year After Acute Myocardial Infarction. JAMA Network Open 2018, 1: e181079-e181079. PMID: 30646102, PMCID: PMC6324290, DOI: 10.1001/jamanetworkopen.2018.1079.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMajor cardiovascular eventsCardiovascular eventsRisk factorsC-statisticMyocardial infarctionAggressive risk factor reductionOne-year event ratesSubsequent major cardiovascular eventsRecurrent acute myocardial infarctionIndex AMI hospitalizationRisk factor reductionHigh-risk patientsProspective cohort studyCoronary heart diseaseLow-risk groupAcute care hospitalsCohort studyCommon comorbiditiesHeart failureMean ageRisk modelHeart diseaseMAIN OUTCOMEHigh risk
2017
Trends in acute pericarditis hospitalizations and outcomes among the elderly in the USA, 1999–2012
Mody P, Bikdeli B, Wang Y, Imazio M, Krumholz HM. Trends in acute pericarditis hospitalizations and outcomes among the elderly in the USA, 1999–2012. European Heart Journal - Quality Of Care And Clinical Outcomes 2017, 4: 98-105. PMID: 29106473, PMCID: PMC6279101, DOI: 10.1093/ehjqcco/qcx040.Peer-Reviewed Original ResearchConceptsLength of stayHospitalization ratesMortality rateReadmission ratesStudy periodCause readmission rateCause mortality ratesLong-term outcomesPrincipal discharge diagnosisRisk of pericarditisHealth care expendituresAcute pericarditisCardiac surgeryRenal diseaseDischarge diagnosisPericarditisHigh riskMedicare beneficiariesHospitalizationOlder adultsCare expendituresStayOutcomesRiskCauseSex Differences in Trajectories of Risk After Rehospitalization for Heart Failure, Acute Myocardial Infarction, or Pneumonia
Dreyer RP, Dharmarajan K, Hsieh AF, Welsh J, Qin L, Krumholz HM. Sex Differences in Trajectories of Risk After Rehospitalization for Heart Failure, Acute Myocardial Infarction, or Pneumonia. Circulation Cardiovascular Quality And Outcomes 2017, 10: e003271. PMID: 28506980, PMCID: PMC5650228, DOI: 10.1161/circoutcomes.116.003271.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionHeart failureReadmission riskDaily riskImmediate postdischarge periodRisk of rehospitalizationSex differencesDeath 1 yearPrincipal discharge diagnosisHospitalization of patientsAssociation of sexRehospitalization riskPostdischarge periodDischarge diagnosisMedicare patientsHigh riskMortality riskMedicare feeTrajectories of riskRehospitalizationInfarctionService beneficiariesHospitalizationPneumoniaYoung Women With Acute Myocardial Infarction
Dreyer RP, Sciria C, Spatz ES, Safdar B, D'Onofrio G, Krumholz HM. Young Women With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2017, 10: e003480. PMID: 28228455, PMCID: PMC5502480, DOI: 10.1161/circoutcomes.116.003480.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionYoung womenMyocardial infarctionManagement of AMIPost-AMI periodContinuum of careCoronary diseaseAged menHigh riskWorse recoveryWomenInfarctionHighlight gapsRecent studiesDifferent mechanismsMorbidityHospitalMortalityEpidemiologyPublic awarenessDiseaseDiagnosisCareSex Differences in 1-Year All-Cause Rehospitalization in Patients After Acute Myocardial Infarction
Dreyer RP, Dharmarajan K, Kennedy KF, Jones PG, Vaccarino V, Murugiah K, Nuti SV, Smolderen KG, Buchanan DM, Spertus JA, Krumholz HM. Sex Differences in 1-Year All-Cause Rehospitalization in Patients After Acute Myocardial Infarction. Circulation 2017, 135: 521-531. PMID: 28153989, PMCID: PMC5312975, DOI: 10.1161/circulationaha.116.024993.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionAge-sex interactionHigh riskRehospitalization ratesClinical factorsMyocardial infarctionCox proportional hazards modelSignificant age-sex interactionCause rehospitalization rateSex differencesMedical record abstractionProportional hazards modelYears of ageFirst yearTRIUMPH studyCause rehospitalizationRecord abstractionPatient interviewsRehospitalizationUS CentersHazards modelPsychosocial factorsPhysician panelHealth statusPsychosocial state
2016
Underweight, Markers of Cachexia, and Mortality in Acute Myocardial Infarction: A Prospective Cohort Study of Elderly Medicare Beneficiaries
Bucholz EM, Krumholz HA, Krumholz HM. Underweight, Markers of Cachexia, and Mortality in Acute Myocardial Infarction: A Prospective Cohort Study of Elderly Medicare Beneficiaries. PLOS Medicine 2016, 13: e1001998. PMID: 27093615, PMCID: PMC4836735, DOI: 10.1371/journal.pmed.1001998.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overBody Mass IndexCachexiaComorbidityFemaleFrail ElderlyGeriatric AssessmentHospital MortalityHumansInsurance BenefitsKaplan-Meier EstimateMaleMedicareMyocardial InfarctionNutrition AssessmentNutritional StatusPrevalencePrognosisProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsThinnessTime FactorsUnited StatesConceptsLower body mass indexNormal weight patientsBody mass indexAcute myocardial infarctionUnderweight patientsWeight patientsSubset of patientsHigh riskFrailty measuresLaboratory markersMyocardial infarctionMedicare beneficiariesNutritional statusCox proportional hazards regressionUnderweight body mass indexMarkers of cachexiaLong-term mortalityProspective cohort studyCohort-based studyMeasures of frailtyProportional hazards regressionCooperative Cardiovascular ProjectElderly Medicare beneficiariesImportant risk factorSignificant chronic illness