2015
National assessment of early β-blocker therapy in patients with acute myocardial infarction in China, 2001-2011: The China Patient-centered Evaluative Assessment of Cardiac Events (PEACE)–Retrospective AMI Study
Zhang H, Masoudi FA, Li J, Wang Q, Li X, Spertus JA, Ross JS, Desai NR, Krumholz HM, Jiang L, Group C. National assessment of early β-blocker therapy in patients with acute myocardial infarction in China, 2001-2011: The China Patient-centered Evaluative Assessment of Cardiac Events (PEACE)–Retrospective AMI Study. American Heart Journal 2015, 170: 506-515.e1. PMID: 26385034, PMCID: PMC5459420, DOI: 10.1016/j.ahj.2015.05.012.Peer-Reviewed Original ResearchConceptsΒ-blocker therapyAcute myocardial infarctionΒ-blocker useCardiogenic shockRisk factorsAbsolute contraindicationMyocardial infarctionEarly β-blocker useLower systolic blood pressureHours of admissionMedical record reviewSystolic blood pressureClinical practice guidelinesLower heart rateQuality of careChest discomfortCardiac eventsBlood pressureRecord reviewChina PatientIdeal patientPractice guidelinesHeart rateHigh riskPatterns of use
2011
Association of Door-In to Door-Out Time With Reperfusion Delays and Outcomes Among Patients Transferred for Primary Percutaneous Coronary Intervention
Wang TY, Nallamothu BK, Krumholz HM, Li S, Roe MT, Jollis JG, Jacobs AK, Holmes DR, Peterson ED, Ting HH. Association of Door-In to Door-Out Time With Reperfusion Delays and Outcomes Among Patients Transferred for Primary Percutaneous Coronary Intervention. JAMA 2011, 305: 2540-2547. PMID: 21693742, DOI: 10.1001/jama.2011.862.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCohort StudiesFemaleHospital MortalityHumansMaleMiddle AgedMyocardial InfarctionMyocardial ReperfusionOdds RatioPatient AdmissionPatient DischargePatient TransferQuality Indicators, Health CareReferral and ConsultationRetrospective StudiesTime FactorsTreatment OutcomeUnited StatesConceptsPrimary percutaneous coronary interventionST-elevation myocardial infarctionPrimary PCIPercutaneous coronary interventionDIDO timeHospital mortalityDTB timeCoronary interventionReperfusion delayFirst hospital presentationMedian DIDO timeOff-hour presentationSTEMI referral hospitalsClinical performance measuresHospital presentationAbsolute contraindicationBalloon timeRetrospective cohortReferral hospitalInterhospital transferACTION RegistryFemale sexMyocardial infarctionFirst HospitalPatient outcomes
2007
Acute Coronary Care in the Elderly, Part II
Alexander KP, Newby LK, Armstrong PW, Cannon CP, Gibler WB, Rich MW, Van de Werf F, White HD, Weaver WD, Naylor MD, Gore JM, Krumholz HM, Ohman EM. Acute Coronary Care in the Elderly, Part II. Circulation 2007, 115: 2570-2589. PMID: 17502591, DOI: 10.1161/circulationaha.107.182616.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAge FactorsAgedAged, 80 and overAngina, UnstableAngioplasty, Balloon, CoronaryCardiovascular AgentsClinical Trials as TopicCombined Modality TherapyDisease ManagementDisease SusceptibilityEvidence-Based MedicineFemaleFibrinolytic AgentsGeriatricsHumansMaleMiddle AgedMulticenter Studies as TopicMyocardial InfarctionMyocardial RevascularizationPatient RightsPractice Guidelines as TopicPrejudiceQuality of LifeRegistriesRisk FactorsStentsThrombolytic TherapyTreatment OutcomeConceptsST-segment elevation myocardial infarctionElderly patientsMyocardial infarctionInvasive treatmentAmerican Heart Association scientific statementOlder adultsComplex health statusGuideline-recommended careTreatment-associated risksAcute coronary syndromeAcute coronary careTreatment-related benefitsAge 85 yearsPatient-centered mannerQuality of lifeLimited trial dataCoronary syndromeReperfusion strategyAbsolute contraindicationAdjunctive therapyCardiovascular medicationsOlder patientsCoronary careGeriatric conditionsElderly subgroup
1997
Thrombolytic Therapy for Eligible Elderly Patients With Acute Myocardial Infarction
Krumholz HM, Murillo JE, Chen J, Vaccarino V, Radford MJ, Ellerbeck EF, Wang Y. Thrombolytic Therapy for Eligible Elderly Patients With Acute Myocardial Infarction. JAMA 1997, 277: 1683-1688. PMID: 9169894, DOI: 10.1001/jama.1997.03540450039032.Peer-Reviewed Original ResearchConceptsST-segment elevationAcute myocardial infarctionThrombolytic therapyBundle branch blockMyocardial infarctionChest painElderly patientsMental statusBranch blockTotal ST-segment elevationEligible elderly patientsThrombolytic therapy useRetrospective cohort studyHours of symptomsOnset of symptomsPopulation-based sampleLack of treatmentDirect angioplastyEligible patientsAbsolute contraindicationBypass surgeryCohort studyMedical chartsTherapy useContiguous leads
1995
Aspirin in the treatment of acute myocardial infarction in elderly Medicare beneficiaries. Patterns of use and outcomes.
Krumholz H, Radford M, Ellerbeck E, Hennen J, Meehan T, Petrillo M, Wang Y, Kresowik T, Jencks S. Aspirin in the treatment of acute myocardial infarction in elderly Medicare beneficiaries. Patterns of use and outcomes. Circulation 1995, 92: 2841-7. PMID: 7586250, DOI: 10.1161/01.cir.92.10.2841.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionUse of aspirinDays of hospitalizationElderly patientsMyocardial infarctionMedicare beneficiariesHospital medical recordsElderly Medicare beneficiariesHigh-risk characteristicsPopulation-based sampleDelivery of careQuality of careAspirin therapyMore comorbiditiesAspirin useChest painAbsolute contraindicationHeart failureThrombolytic therapyPotential confoundersMedical recordsSafe treatmentEffective therapyHigh riskLower odds