2024
Targeting hypoxia and thrombospondin‐2 in diabetic wound healing
Huang Y, Xing H, Naud S, Kyriakides T. Targeting hypoxia and thrombospondin‐2 in diabetic wound healing. The FASEB Journal 2024, 38: e70091. PMID: 39383062, PMCID: PMC11486302, DOI: 10.1096/fj.202302429rrr.Peer-Reviewed Original ResearchConceptsThrombospondin-2Diabetic miceWound healingHIF-1aMatricellular protein thrombospondin-2Diabetic woundsImpaired wound healingWounds of diabetic miceDimethyloxalylglycine treatmentTargeting hypoxiaSustained hypoxiaDiabetic patientsTSP2 expressionCell dysfunctionIncreased neovascularizationDiabetic wound healingGenetic ablationDiabetic fibroblastsElevated glucoseReduced hypoxiaImprove healingImmunofluorescence analysisHIF-1a activationHypoxiaWestern blotting
2018
Interstitial flow promotes macrophage polarization toward an M2 phenotype
Li R, Serrano J, Xing H, Lee T, Azizgolshani H, Zaman M, Kamm R. Interstitial flow promotes macrophage polarization toward an M2 phenotype. Molecular Biology Of The Cell 2018, 29: 1927-1940. PMID: 29995595, PMCID: PMC6232969, DOI: 10.1091/mbc.e18-03-0164.Peer-Reviewed Original ResearchConceptsPromote cancer cell migrationTumor microenvironmentCancer cell migrationCancer cell invasionTumor progressionTumor tissuesTumor immune environmentSurrounding stromal tissueMechanotransduction pathwaysCell migrationInterstitial fluid flowCell invasionInterstitial flowInduced M2 polarizationM2 polarization of macrophagesPolarization of macrophagesFluid flowTumor massImmune environmentInduce M2 polarization of macrophagesSurrounding stromaStromal tissuePhenotypeM2 macrophagesTumor