2018
Interstitial flow promotes macrophage polarization toward an M2 phenotype
Li R, Serrano J, Xing H, Lee T, Azizgolshani H, Zaman M, Kamm R. Interstitial flow promotes macrophage polarization toward an M2 phenotype. Molecular Biology Of The Cell 2018, 29: 1927-1940. PMID: 29995595, PMCID: PMC6232969, DOI: 10.1091/mbc.e18-03-0164.Peer-Reviewed Original ResearchConceptsPromote cancer cell migrationTumor microenvironmentCancer cell migrationCancer cell invasionTumor progressionTumor tissuesTumor immune environmentSurrounding stromal tissueMechanotransduction pathwaysCell migrationInterstitial fluid flowCell invasionInterstitial flowInduced M2 polarizationM2 polarization of macrophagesPolarization of macrophagesFluid flowTumor massImmune environmentInduce M2 polarization of macrophagesSurrounding stromaStromal tissuePhenotypeM2 macrophagesTumor
2017
Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways
Li R, Hebert J, Lee T, Xing H, Boussommier-Calleja A, Hynes R, Lauffenburger D, Kamm R. Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways. Cancer Research 2017, 77: 279-290. PMID: 27872091, PMCID: PMC5243269, DOI: 10.1158/0008-5472.can-16-0442.Peer-Reviewed Original ResearchConceptsCancer cellsExtracellular matrixCancer cell migrationMigration speedCancer cell metastasisCell migration assayMigration persistenceSolid tumorsPersistence of cancer cellsCell migrationMT1-MMP expressionSynergistic inductionDeterminants of metastasisCell metastasisMT1-MMPMigration assayPresence of macrophagesAntimetastatic strategyDual blockadeTumor microenvironmentTissue cultureTGFB1Dense extracellular matrixCellsMetastasis