Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways
Li R, Hebert J, Lee T, Xing H, Boussommier-Calleja A, Hynes R, Lauffenburger D, Kamm R. Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways. Cancer Research 2017, 77: 279-290. PMID: 27872091, PMCID: PMC5243269, DOI: 10.1158/0008-5472.can-16-0442.Peer-Reviewed Original ResearchConceptsCancer cellsExtracellular matrixCancer cell migrationMigration speedCancer cell metastasisCell migration assayMigration persistenceSolid tumorsPersistence of cancer cellsCell migrationMT1-MMP expressionSynergistic inductionDeterminants of metastasisCell metastasisMT1-MMPMigration assayPresence of macrophagesAntimetastatic strategyDual blockadeTumor microenvironmentTissue cultureTGFB1Dense extracellular matrixCellsMetastasis