Interstitial flow promotes macrophage polarization toward an M2 phenotype
Li R, Serrano J, Xing H, Lee T, Azizgolshani H, Zaman M, Kamm R. Interstitial flow promotes macrophage polarization toward an M2 phenotype. Molecular Biology Of The Cell 2018, 29: 1927-1940. PMID: 29995595, PMCID: PMC6232969, DOI: 10.1091/mbc.e18-03-0164.Peer-Reviewed Original ResearchConceptsPromote cancer cell migrationTumor microenvironmentCancer cell migrationCancer cell invasionTumor progressionTumor tissuesTumor immune environmentSurrounding stromal tissueMechanotransduction pathwaysCell migrationInterstitial fluid flowCell invasionInterstitial flowInduced M2 polarizationM2 polarization of macrophagesPolarization of macrophagesFluid flowTumor massImmune environmentInduce M2 polarization of macrophagesSurrounding stromaStromal tissuePhenotypeM2 macrophagesTumor