2019
Extracellular matrix-derived biomaterials in engineering cell function
Xing H, Lee H, Luo L, Kyriakides TR. Extracellular matrix-derived biomaterials in engineering cell function. Biotechnology Advances 2019, 42: 107421. PMID: 31381963, PMCID: PMC6995418, DOI: 10.1016/j.biotechadv.2019.107421.Peer-Reviewed Educational MaterialsConceptsTissue-derived extracellular matrixECM proteinsExtracellular matrixCell-derived extracellular matrixSingle ECM proteinsStem cell differentiationCell functionCell-specific responsesGuide cell migrationEngineering of biomaterialsCell differentiationECM environmentECM polymersCell adhesionNative stateCell migrationProteinUse of biomaterialsMaterial coatingEnhanced cell adhesionBiomaterialsCell isolationDecellularization technologyRecent advancesDermal repair
2018
Decellularized materials derived from TSP2-KO mice promote enhanced neovascularization and integration in diabetic wounds
Morris AH, Stamer DK, Kunkemoeller B, Chang J, Xing H, Kyriakides TR. Decellularized materials derived from TSP2-KO mice promote enhanced neovascularization and integration in diabetic wounds. Biomaterials 2018, 169: 61-71. PMID: 29631168, PMCID: PMC5933884, DOI: 10.1016/j.biomaterials.2018.03.049.Peer-Reviewed Original ResearchConceptsUltimate tensile strengthECM-based materialsTensile strengthMechanical testingDecellularized materialsElastic modulusSynthetic biomaterialsIntact slabsMatrix propertiesExtracellular matrix propertiesCell-derived ECMBiologic scaffoldsElectron microscopyEngineering controlsMaterialsWtEfficient integrationEnhanced vascularizationModulusPromigratory propertiesScaffoldsPropertiesBiomaterialsEnhanced remodelingGreater cell migration