2024
Fibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) – protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids
Al-Hendy A, Segars J, Taylor H, González F, Siblini H, Zamah M, Alkelani H, Singh B, Flores V, Christman G, Johnson J, Huang H, Zhang H. Fibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) – protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids. BMJ Open 2024, 14: e078989. PMID: 38216200, PMCID: PMC10806662, DOI: 10.1136/bmjopen-2023-078989.Peer-Reviewed Original ResearchConceptsUnexplained infertilityIntrauterine inseminationInstitutional review boardCumulative live birth rateUterine fibroidsLive birth rateCause of infertilityFood and Drug AdminstrationGonadotropin hormone-releasing hormoneGreen tea extractDouble-blind clinical trialNon-surgical treatment optionsTimed intrauterine inseminationUterine fibroid sizeOvarian stimulationQuality of Life Questionnaire scoresHormone-releasing hormoneLocal institutional review boardInfertility treatmentNational Institute of Child HealthInstitute of Child HealthMiscarriage rateBirth rateReproductive-age womenEndometrial quality
2023
Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women
Siblini H, Al-Hendy A, Segars J, González F, Taylor H, Singh B, Flaminia A, Flores V, Christman G, Huang H, Johnson J, Zhang H. Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women. Nutrients 2023, 15: 320. PMID: 36678191, PMCID: PMC9861948, DOI: 10.3390/nu15020320.Peer-Reviewed Original ResearchConceptsReproductive-aged womenLiver function testsUterine fibroidsUnexplained infertilityClomiphene citrateSerum liver function testsEpigallocatechin gallateSigns of drugSerum folate levelsGreen tea catechinsHepatic safetyPremenopausal womenProspective cohortDaily doseLiver injuryFunction testsTreatment armsLiver toxicityClinical studiesCommon causeFolate levelsEarly safety assessmentInterim analysisNormal rangeUse of EGCG
2022
Effects of preconception lifestyle intervention in infertile women with obesity: The FIT-PLESE randomized controlled trial
Legro RS, Hansen KR, Diamond MP, Steiner AZ, Coutifaris C, Cedars MI, Hoeger KM, Usadi R, Johnstone EB, Haisenleder DJ, Wild RA, Barnhart KT, Mersereau J, Trussell JC, Krawetz SA, Kris-Etherton PM, Sarwer DB, Santoro N, Eisenberg E, Huang H, Zhang H, . Effects of preconception lifestyle intervention in infertile women with obesity: The FIT-PLESE randomized controlled trial. PLOS Medicine 2022, 19: e1003883. PMID: 35041662, PMCID: PMC8765626, DOI: 10.1371/journal.pmed.1003883.Peer-Reviewed Original ResearchConceptsHealthy live birthIntensive lifestyle interventionLifestyle interventionLive birthsWeight lossExercise interventionPrimary outcomeBirth outcomesMetabolic healthInfertility treatmentPhysical activityOvarian stimulation/intrauterine inseminationIntensive groupFirst trimester pregnancy lossIntensive lifestyle groupLifestyle modification groupPreconception lifestyle interventionStandard exercise interventionAcute weight lossTrimester pregnancy lossGastrointestinal side effectsSignificant weight lossLive birth incidenceLifestyle groupUnexplained infertility
2021
Sleep Habits of Women With Infertility
Eisenberg E, Legro RS, Diamond MP, Huang H, O’Brien L, Smith YR, Coutifaris C, Hansen KR, Santoro N, Zhang H. Sleep Habits of Women With Infertility. The Journal Of Clinical Endocrinology & Metabolism 2021, 106: e4414-e4426. PMID: 34180998, PMCID: PMC8530742, DOI: 10.1210/clinem/dgab474.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeShort sleep durationUnexplained infertilityHabitual snoringClinical symptomsSleep durationInfertile womenSleep disturbancesClinical trialsLive birth rateObstructive sleep apneaRandomized clinical trialsMain outcome measuresObstructive sleep apnea diagnosisSelf-reported sleep measuresClinical depression scoresSleep apnea diagnosisAmbulatory gynecologyCurrent smokingOvary syndromePCOS diagnosisProspective cohortSleep apneaInfertility practicePrevious diagnosis
2020
Pregnancy registry: three-year follow-up of children conceived from letrozole, clomiphene, or gonadotropins
Legro RS, Diamond MP, Coutifaris C, Schlaff WD, Alvero R, Casson P, Christman GM, Rosen RM, Cedars MI, Hansen KR, Robinson R, Baker V, Usadi R, Dodson WC, Estes SJ, Kunselman A, Stetter C, Barnhart KT, Coward RM, Trussell JC, Krawetz SA, Santoro N, Huang H, Zhang H, Eisenberg E, Network R. Pregnancy registry: three-year follow-up of children conceived from letrozole, clomiphene, or gonadotropins. Fertility And Sterility 2020, 113: 1005-1013. PMID: 32386612, PMCID: PMC7376442, DOI: 10.1016/j.fertnstert.2019.12.023.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsChild BehaviorChild DevelopmentChild, PreschoolClomipheneCognitionFemaleFertilityFertility AgentsFollow-Up StudiesGesturesGonadotropinsHumansInfantInfertility, FemaleLetrozoleLive BirthMaleOvulation InductionPolycystic Ovary SyndromePregnancyProspective StudiesRandomized Controlled Trials as TopicRegistriesTreatment OutcomeUnited StatesWeight GainConceptsGN groupMultiple pregnancy rateProspective cohort studyPolycystic ovary syndromeChildren of womenInfertility trialsUnexplained infertilityCohort studyII studyMultiple gestationsOvary syndromeHealth centersInfertility treatmentPregnancy rateInfertility therapyMAIN OUTCOMELTZ groupLetrozoleMacArthur-Bates Communicative Development InventoriesAcademic health centersGonadotropinAbnormal scoresClomipheneCC groupDevelopmental Questionnaire
2019
Lower prevalence of non–cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility
Huang H, Kuang H, Sun F, Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson PR, Christman GM, Hansen KR, Santoro N, Eisenberg E, Zhang H, Network E. Lower prevalence of non–cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility. Fertility And Sterility 2019, 111: 1011-1019.e1. PMID: 30926125, PMCID: PMC6487215, DOI: 10.1016/j.fertnstert.2019.01.020.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeUnexplained infertilityUterine fibroidsLow prevalenceOvary syndromeDifferent body mass index (BMI) groupsBody mass index groupsHigher body mass indexHigher total testosteroneNormal uterine cavityAssessment-insulin resistanceBody mass indexRandomized clinical trialsCurrent alcohol usersPrevalence of womenTotal testosteroneCurrent smokersInfertile womenLarge fibroidsMass indexInfertile patientsInsulin resistanceUterine cavityClinical trialsLower percentage
2017
Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility
Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson PA, Christman GM, Huang H, Hansen KR, Baker V, Usadi R, Seungdamrong A, Bates GW, Rosen RM, Schlaff W, Haisenleder D, Krawetz SA, Barnhart K, Trussell JC, Santoro N, Eisenberg E, Zhang H, Network E. Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility. American Journal Of Obstetrics And Gynecology 2017, 217: 191.e1-191.e19. PMID: 28455078, PMCID: PMC5657185, DOI: 10.1016/j.ajog.2017.04.034.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeFemale Sexual Function InventoryUnexplained infertilityOvary syndromeSexual Function InventorySexual functionInfertile womenSexual dysfunctionEunice Kennedy Shriver National InstituteFemale Sexual Distress ScaleTotal scoreMultiple Intrauterine GestationsFree androgen indexReproductive-age womenSexual function scoresBody mass indexFemale sexual functionFemale sexual dysfunctionSexual Distress ScaleScale total scoreAndrogenic manifestationsAndrogen indexOvarian stimulationAndrogen excessIntrauterine gestation
2015
Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility
Diamond M, Legro R, Coutifaris C, Alvero R, Robinson R, Casson P, Christman G, Ager J, Huang H, Hansen K, Baker V, Usadi R, Seungdamrong A, Bates G, Rosen R, Haisenleder D, Krawetz S, Barnhart K, Trussell J, Ohl D, Jin Y, Santoro N, Eisenberg E, Zhang H. Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility. Obstetrical & Gynecological Survey 2015, 70: 757-758. DOI: 10.1097/ogx.0000000000000275.Peer-Reviewed Original ResearchOvarian stimulationUnexplained infertilityMultiple gestationsLetrozole groupCongenital anomaliesPregnancy rateLive birthsNormal uterine cavityStandard therapy groupUse of clomipheneOvarian hyperstimulation syndromeFirst-line therapyLive birth ratePatent fallopian tubesPolycystic ovary syndromeMultiple gestation ratesCause of infertilityPlacebo control groupNormal sperm countYears of ageImproved pregnancy ratesFetal heart activityHyperstimulation syndromeMonofollicular developmentNeonatal complicationsLetrozole, Gonadotropin, or Clomiphene for Unexplained Infertility
Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Ager J, Huang H, Hansen KR, Baker V, Usadi R, Seungdamrong A, Bates GW, Rosen RM, Haisenleder D, Krawetz SA, Barnhart K, Trussell JC, Ohl D, Jin Y, Santoro N, Eisenberg E, Zhang H. Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility. New England Journal Of Medicine 2015, 373: 1230-1240. PMID: 26398071, PMCID: PMC4739644, DOI: 10.1056/nejmoa1414827.Peer-Reviewed Original ResearchConceptsUnexplained infertilityMultiple gestationsOvarian stimulationClinical pregnancyStandard therapyLive birth ratePatent fallopian tubesMultiple gestation ratesYears of ageFetal heart activityLetrozole groupNeonatal complicationsClomiphene citrateTriplet gestationsOngoing pregnancyPrimary outcomeGonadotropin treatmentFallopian tubeGestation rateCongenital anomaliesPregnancy rateWomen 18Live birthsClomipheneLetrozole