2024
Fibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) – protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids
Al-Hendy A, Segars J, Taylor H, González F, Siblini H, Zamah M, Alkelani H, Singh B, Flores V, Christman G, Johnson J, Huang H, Zhang H. Fibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) – protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids. BMJ Open 2024, 14: e078989. PMID: 38216200, PMCID: PMC10806662, DOI: 10.1136/bmjopen-2023-078989.Peer-Reviewed Original ResearchConceptsUnexplained infertilityIntrauterine inseminationInstitutional review boardCumulative live birth rateUterine fibroidsLive birth rateCause of infertilityFood and Drug AdminstrationGonadotropin hormone-releasing hormoneGreen tea extractDouble-blind clinical trialNon-surgical treatment optionsTimed intrauterine inseminationUterine fibroid sizeOvarian stimulationQuality of Life Questionnaire scoresHormone-releasing hormoneLocal institutional review boardInfertility treatmentNational Institute of Child HealthInstitute of Child HealthMiscarriage rateBirth rateReproductive-age womenEndometrial quality
2022
Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial
Taylor H, Li HJ, Carson S, Flores V, Pal L, Robbins J, Santoro NF, Segars JH, Seifer D, Huang H, Young S, Zhang H. Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial. BMJ Open 2022, 12: e052043. PMID: 35715184, PMCID: PMC9207753, DOI: 10.1136/bmjopen-2021-052043.Peer-Reviewed Original ResearchConceptsEndometriosis-associated infertilityPlacebo-controlled trialGnRH antagonistFertility treatmentOral GnRH antagonistEndometriosis-related infertilityFertilization-embryo transferLive birth rateUse of gonadotropinsEtiology of infertilityInstitutional review boardAntagonist pretreatmentCommon complicationObstetrical outcomesPeer-reviewed journalsSecondary outcomesIVF treatmentPrimary outcomeHormone agonistImplantation ratePregnancy rateLive birthsEndometriosisLocal protocolsOocyte number
2021
Sleep Habits of Women With Infertility
Eisenberg E, Legro RS, Diamond MP, Huang H, O’Brien L, Smith YR, Coutifaris C, Hansen KR, Santoro N, Zhang H. Sleep Habits of Women With Infertility. The Journal Of Clinical Endocrinology & Metabolism 2021, 106: e4414-e4426. PMID: 34180998, PMCID: PMC8530742, DOI: 10.1210/clinem/dgab474.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeShort sleep durationUnexplained infertilityHabitual snoringClinical symptomsSleep durationInfertile womenSleep disturbancesClinical trialsLive birth rateObstructive sleep apneaRandomized clinical trialsMain outcome measuresObstructive sleep apnea diagnosisSelf-reported sleep measuresClinical depression scoresSleep apnea diagnosisAmbulatory gynecologyCurrent smokingOvary syndromePCOS diagnosisProspective cohortSleep apneaInfertility practicePrevious diagnosis
2020
The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial
Steiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Coward RM, Huang H, Wild R, Masson P, Smith JF, Santoro N, Eisenberg E, Zhang H, Network R. The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Fertility And Sterility 2020, 113: 552-560.e3. PMID: 32111479, PMCID: PMC7219515, DOI: 10.1016/j.fertnstert.2019.11.008.Peer-Reviewed Original ResearchConceptsMonths of treatmentMale factor infertilityFactor infertilityLive birthsSemen parametersPlacebo groupPrimary outcomeSperm concentrationPlacebo-controlled trialLive birth rateCumulative live birthDNA fragmentationFemale partnersSperm DNA fragmentation indexLycopene dailyVivo pregnancyClomiphene citrateSecondary outcomesEntire cohortAsthenospermic menFertility centerIntrauterine inseminationMonth 4Tubal patencyClinical trials
2015
Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility
Diamond M, Legro R, Coutifaris C, Alvero R, Robinson R, Casson P, Christman G, Ager J, Huang H, Hansen K, Baker V, Usadi R, Seungdamrong A, Bates G, Rosen R, Haisenleder D, Krawetz S, Barnhart K, Trussell J, Ohl D, Jin Y, Santoro N, Eisenberg E, Zhang H. Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility. Obstetrical & Gynecological Survey 2015, 70: 757-758. DOI: 10.1097/ogx.0000000000000275.Peer-Reviewed Original ResearchOvarian stimulationUnexplained infertilityMultiple gestationsLetrozole groupCongenital anomaliesPregnancy rateLive birthsNormal uterine cavityStandard therapy groupUse of clomipheneOvarian hyperstimulation syndromeFirst-line therapyLive birth ratePatent fallopian tubesPolycystic ovary syndromeMultiple gestation ratesCause of infertilityPlacebo control groupNormal sperm countYears of ageImproved pregnancy ratesFetal heart activityHyperstimulation syndromeMonofollicular developmentNeonatal complicationsLetrozole, Gonadotropin, or Clomiphene for Unexplained Infertility
Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Ager J, Huang H, Hansen KR, Baker V, Usadi R, Seungdamrong A, Bates GW, Rosen RM, Haisenleder D, Krawetz SA, Barnhart K, Trussell JC, Ohl D, Jin Y, Santoro N, Eisenberg E, Zhang H. Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility. New England Journal Of Medicine 2015, 373: 1230-1240. PMID: 26398071, PMCID: PMC4739644, DOI: 10.1056/nejmoa1414827.Peer-Reviewed Original ResearchConceptsUnexplained infertilityMultiple gestationsOvarian stimulationClinical pregnancyStandard therapyLive birth ratePatent fallopian tubesMultiple gestation ratesYears of ageFetal heart activityLetrozole groupNeonatal complicationsClomiphene citrateTriplet gestationsOngoing pregnancyPrimary outcomeGonadotropin treatmentFallopian tubeGestation rateCongenital anomaliesPregnancy rateWomen 18Live birthsClomipheneLetrozole
2012
Predictors of pregnancy and live birth after insemination in couples with unexplained or male-factor infertility
Huang H, Hansen KR, Factor-Litvak P, Carson SA, Guzick DS, Santoro N, Diamond MP, Eisenberg E, Zhang H, Network I. Predictors of pregnancy and live birth after insemination in couples with unexplained or male-factor infertility. Fertility And Sterility 2012, 97: 959-967.e5. PMID: 22270557, PMCID: PMC3319287, DOI: 10.1016/j.fertnstert.2012.01.090.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAlcohol DrinkingAlcoholic BeveragesChi-Square DistributionCoffeeFemaleHumansInfertilityInfertility, MaleInsemination, ArtificialLife StyleLive BirthLogistic ModelsMaleMiddle AgedMultivariate AnalysisOvulation InductionPregnancyPregnancy RateProspective StudiesRisk AssessmentRisk FactorsRisk Reduction BehaviorSuperovulationSurveys and QuestionnairesTeaTreatment OutcomeUnited StatesYoung AdultConceptsLive birth rateMale factor infertilityLive birthsPregnancy outcomesHigher pregnancyBirth ratePredictors of pregnancyAlcoholic beveragesFemale partnersOccurrence of pregnancyAcademic medical centerLifestyle factorsIntrauterine inseminationRisk factorsLifestyle questionnaireOccupational exposureMedical CenterLifestyle changesMAIN OUTCOMETreatment groupsPregnancySecondary analysisPast usersCurrent usersBirth