2016
In vitro functional screening as a means to identify new plasticizers devoid of reproductive toxicity
Boisvert A, Jones S, Issop L, Erythropel HC, Papadopoulos V, Culty M. In vitro functional screening as a means to identify new plasticizers devoid of reproductive toxicity. Environmental Research 2016, 150: 496-512. PMID: 27423704, DOI: 10.1016/j.envres.2016.06.033.Peer-Reviewed Original ResearchConceptsOrgan cultureDose-response studySensitive developmental windowsFetal Leydig cellsGerm cellsAndrogen productionTesticular functionBiphasic effectSteroid productionReproductive toxicityLeydig cellsSpermatogonial cell lineMonoester metabolitesNeonatal testisSafe alternativeScreening toolDevelopment of compoundsVivo evaluationCell linesMA-10Developmental windowCell line dataCell survivalEndocrine disruptorsPromising compounds
2012
Effects of di-(2-ethylhexyl) phthalate and four of its metabolites on steroidogenesis in MA-10 cells
Piché CD, Sauvageau D, Vanlian M, Erythropel HC, Robaire B, Leask RL. Effects of di-(2-ethylhexyl) phthalate and four of its metabolites on steroidogenesis in MA-10 cells. Ecotoxicology And Environmental Safety 2012, 79: 108-115. PMID: 22236953, DOI: 10.1016/j.ecoenv.2011.12.008.Peer-Reviewed Original Research