In vitro functional screening as a means to identify new plasticizers devoid of reproductive toxicity
Boisvert A, Jones S, Issop L, Erythropel HC, Papadopoulos V, Culty M. In vitro functional screening as a means to identify new plasticizers devoid of reproductive toxicity. Environmental Research 2016, 150: 496-512. PMID: 27423704, DOI: 10.1016/j.envres.2016.06.033.Peer-Reviewed Original ResearchConceptsOrgan cultureDose-response studySensitive developmental windowsFetal Leydig cellsGerm cellsAndrogen productionTesticular functionBiphasic effectSteroid productionReproductive toxicityLeydig cellsSpermatogonial cell lineMonoester metabolitesNeonatal testisSafe alternativeScreening toolDevelopment of compoundsVivo evaluationCell linesMA-10Developmental windowCell line dataCell survivalEndocrine disruptorsPromising compounds