Toxicogenomic Screening of Replacements for Di(2-Ethylhexyl) Phthalate (DEHP) Using the Immortalized TM4 Sertoli Cell Line
Nardelli TC, Erythropel HC, Robaire B. Toxicogenomic Screening of Replacements for Di(2-Ethylhexyl) Phthalate (DEHP) Using the Immortalized TM4 Sertoli Cell Line. PLOS ONE 2015, 10: e0138421. PMID: 26445464, PMCID: PMC4596883, DOI: 10.1371/journal.pone.0138421.Peer-Reviewed Original ResearchConceptsTM4 Sertoli cell lineUpregulated genesSertoli cell lineMajor signal transduction pathwaysCholesterol biosynthesisSignal transduction pathwaysERK/MAPKGene expression studiesCell linesToxicogenomic screeningTransduction pathwaysDNA repairRho signalingDEHP/MEHPExpression studiesGene expressionStress responseGenesToxicogenomic profilesAltered expressionButanediol dibenzoateBiosynthesisMultiple commercial applicationsDioctyl succinateExpression