2024
miR-33 deletion in hepatocytes attenuates NAFLD-NASH-HCC progression
Fernández-Tussy P, Cardelo M, Zhang H, Sun J, Price N, Boutagy N, Goedeke L, Cadena-Sandoval M, Xirouchaki C, Brown W, Yang X, Pastor-Rojo O, Haeusler R, Bennett A, Tiganis T, Suárez Y, Fernández-Hernando C. miR-33 deletion in hepatocytes attenuates NAFLD-NASH-HCC progression. JCI Insight 2024, 9: e168476. PMID: 39190492, PMCID: PMC11466198, DOI: 10.1172/jci.insight.168476.Peer-Reviewed Original ResearchMiR-33Regulation of biological processesMitochondrial fatty acid oxidationRegulation of lipid metabolismNon-alcoholic fatty liver diseaseDevelopment of effective therapeuticsFatty acid oxidationLipid synthesisProgression of non-alcoholic fatty liver diseaseMitochondrial functionTarget genesBiological processesComplex diseasesNon-alcoholic steatohepatitisLipid accumulationDeletionDevelopment of non-alcoholic fatty liver diseasePathway activationLipid metabolismProgress to non-alcoholic steatohepatitisAcid oxidationHCC progressionEffective therapeuticsTherapeutic targetHepatocellular carcinoma
2017
TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux
Pan B, Zhang H, Cui T, Wang X. TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux. Journal Of Molecular And Cellular Cardiology 2017, 113: 51-62. PMID: 28993153, PMCID: PMC5656243, DOI: 10.1016/j.yjmcc.2017.10.003.Peer-Reviewed Original ResearchMeSH KeywordsAlpha-Crystallin B ChainAnimalsAutophagyBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCell SurvivalFemaleHeart DiseasesHeart VentriclesLysosomesMaleMechanistic Target of Rapamycin Complex 1MiceMice, TransgenicMyocytes, CardiacRatsRats, Sprague-DawleyRNA, MessengerSignal TransductionConceptsAutophagic-lysosomal pathwayCardiac proteinopathyAutophagic fluxTFEB target genesTFEB overexpressionActivity of TFEBMRNA levelsMTORC1 activationMaster regulatorUbiquitinated proteinsDownregulation of TFEBGenetic manipulationAutophagic cargoTarget genesMolecular basisProtein aggregatesTFEB activation