2018
Plasma Menthol Glucuronide as a Biomarker of Acute Menthol Inhalation
Jatlow P, Valentine G, Gueorguieva R, Nadim H, Wu R, O'Malley SS, Sofuoglu M. Plasma Menthol Glucuronide as a Biomarker of Acute Menthol Inhalation. Tobacco Regulatory Science 2018, 4: 586-591. PMID: 29479558, PMCID: PMC5822727, DOI: 10.18001/trs.4.1.5.Peer-Reviewed Original ResearchPlasma Mg concentrationHuman challenge studiesMenthol inhalationMenthol glucuronideMenthol exposureChallenge studiesAnti-irritant effectsDose-dependent increaseInhalation of aerosolsE-cigarette solutionsVenous plasmaVenous bloodIntravenous nicotineNicotine dependenceSecondary analysisInhalationE-cigarettesQuantitative biomarkersVulnerable populationsInter-individual differencesAfrican AmericansNicotineMenthol concentrationGlucuronideBiomarkers
2012
Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine
Sofuoglu M, Herman AI, Nadim H, Jatlow P. Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine. Neuropsychopharmacology 2012, 37: 1509-1516. PMID: 22334123, PMCID: PMC3327855, DOI: 10.1038/npp.2011.336.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceCarbon MonoxideChi-Square DistributionChromatography, High Pressure LiquidCotinineDose-Response Relationship, DrugHeart RateHumansHydrocortisoneInjections, IntravenousMaleMiddle AgedNicotineNicotinic AgonistsSingle-Blind MethodSubstance Withdrawal SyndromeTandem Mass SpectrometryTime FactorsYoung AdultConceptsHigher nicotine metabolite ratioNicotine metabolite ratioHeart rate increaseCessation treatmentNicotine clearanceOvernight abstinenceGood drug effectBlood pressure measuresDiastolic blood pressure measuresEffects of nicotinePoor treatment responseNicotine dependence scoresTreatment-seeking smokersGreater heart rate increaseIntravenous dosesNicotine patchPoor outcomeNicotine rewardDrug likingFagerstrom TestTreatment outcomesIntravenous nicotineTreatment responseCigarette cravingHeart rate