2024
Secondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts
Rivier C, Acosta J, Leasure A, Forman R, Sharma R, de Havenon A, Spatz E, Inzucchi S, Kernan W, Falcone G, Sheth K. Secondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts. Journal Of The American Heart Association 2024, 13: e033322. PMID: 38639369, PMCID: PMC11179946, DOI: 10.1161/jaha.123.033322.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsBlood PressureCross-Sectional StudiesFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPractice Guidelines as TopicRisk AssessmentRisk FactorsSecondary PreventionStrokeUnited KingdomUnited StatesConceptsMyocardial infarctionPrevention scoreSecondary preventionImplementation of preventive therapyNational cohortUK BiobankAntiplatelet therapy useGuideline-directed therapyPrevention profilesBlood pressure controlAdherence to guideline-directed therapyLow-density lipoprotein controlNeighborhood deprivation levelHistory of strokeVascular risk profileStatin useAntiplatelet useTherapy usePreventive therapyComparison to participantsPrevention criteriaCross-sectional analysisBlood pressurePatientsPressure control
2019
Antiplatelet Therapy After Spontaneous Intracerebral Hemorrhage and Functional Outcomes
Murthy SB, Biffi A, Falcone GJ, Sansing LH, Torres Lopez V, Navi BB, Roh DJ, Mandava P, Hanley DF, Ziai WC, Kamel H, Rosand J, Sheth KN, Butcher K, Davis S, Gregson B, Lees K, Lyden P, Mayer S, Muir K, Steiner T. Antiplatelet Therapy After Spontaneous Intracerebral Hemorrhage and Functional Outcomes. Stroke 2019, 50: 3057-3063. PMID: 31895618, PMCID: PMC6941441, DOI: 10.1161/strokeaha.119.025972.Peer-Reviewed Original ResearchConceptsAntiplatelet therapyIntracerebral hemorrhageFunctional outcomeHematoma locationCause mortalityMajor disabilityVirtual International Stroke Trials Archive databaseCox proportional regression analysisConclusions Antiplatelet therapyRecurrent intracerebral hemorrhageProportional regression analysisPoor functional outcomeRandomized clinical trialsSpontaneous intracerebral hemorrhagePaucity of dataAntiplatelet medicationsStroke RegistryThromboembolic riskHazard ratioMulticenter cohortPrimary outcomeMedian timeICH patientsClinical trialsMeta-analyzed data
2014
Aspirin Should Be Discontinued After Lobar Intracerebral Hemorrhage
Falcone GJ, Rosand J. Aspirin Should Be Discontinued After Lobar Intracerebral Hemorrhage. Stroke 2014, 45: 3151-3152. PMID: 25205309, DOI: 10.1161/strokeaha.114.005787.Peer-Reviewed Original ResearchAged, 80 and overAspirinCerebral HemorrhageCognition DisordersComorbidityFemaleHumansIschemic Attack, TransientPlatelet Aggregation InhibitorsCT angiography spot sign in intracerebral hemorrhage predicts active bleeding during surgery
Brouwers HB, Raffeld MR, van Nieuwenhuizen KM, Falcone GJ, Ayres AM, McNamara KA, Schwab K, Romero JM, Velthuis BK, Viswanathan A, Greenberg SM, Ogilvy CS, van der Zwan A, Rinkel GJ, Goldstein JN, Klijn CJ, Rosand J. CT angiography spot sign in intracerebral hemorrhage predicts active bleeding during surgery. Neurology 2014, 83: 883-889. PMID: 25098540, PMCID: PMC4153853, DOI: 10.1212/wnl.0000000000000747.Peer-Reviewed Original ResearchConceptsPostoperative rebleedingIntracerebral hemorrhageSpontaneous intracerebral hemorrhageSpot signActive bleedingHematoma evacuationIntraoperative bleedingCase fatalityICH volumeCT angiography spot signBrainstem ICHOnly independent markerSurgical hematoma evacuationSpontaneous ICH patientsMultivariable logistic regressionConsecutive spontaneous ICH patientsFuture surgical trialsSpot sign presenceCTA spot signAntiplatelet usePostoperative bleedingResidual hematomaICH patientsFemale sexSurgical trials