2022
Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis
Kuramatsu JB, Gerner ST, Ziai W, Bardutzky J, Sembill JA, Sprügel MI, Mrochen A, Kölbl K, Ram M, Avadhani R, Falcone GJ, Selim MH, Lioutas VA, Endres M, Zweynert S, Vajkoczy P, Ringleb PA, Purrucker JC, Volkmann J, Neugebauer H, Erbguth F, Schellinger PD, Knappe UJ, Fink GR, Dohmen C, Minnerup J, Reichmann H, Schneider H, Röther J, Reimann G, Schwarz M, Bäzner H, Claßen J, Michalski D, Witte OW, Günther A, Hamann GF, Lücking H, Dörfler A, Ishfaq MF, Chang JJ, Testai FD, Woo D, Alexandrov AV, Staykov D, Goyal N, Tsivgoulis G, Sheth KN, Awad IA, Schwab S, Hanley DF, Huttner HB, Sansing L, Matouk C, Leasure A, Sobesky J, Bauer M, Schurig J, Rizos T, Haeusler K, Müllges W, Kraft P, Schubert A, Stösser S, Ludolph A, Nueckel M, Glahn J, Stetefeld H, Rahmig J, Fisse A, Michels P, Schwert H, Hagemann G, Rakers F, Wöhrle J, Alshammari F, Horn M, Bahner D, Urbanek C, Palm F, Grau A. Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis. Stroke 2022, 53: 2876-2886. PMID: 35521958, PMCID: PMC9398945, DOI: 10.1161/strokeaha.121.038455.Peer-Reviewed Original ResearchConceptsAbsolute treatment effectStandard of careIntraventricular fibrinolysisIntracerebral hemorrhageIntraventricular hemorrhagePrimary outcomeAcute hydrocephalusAdverse eventsFunctional disabilityIVF treatmentFunctional outcomeOdds ratioOrdinal shift analysisIndividual Participant Data Meta-AnalysisModified Rankin ScaleExternal ventricular drainageImproved functional outcomesData Meta-AnalysisPromising therapeutic targetTreatment effectsIndividual participant dataCause mortalityRankin ScaleSecondary outcomesSymptom onset
2012
Confounding by Indication in Retrospective Studies of Intracerebral Hemorrhage: Antiepileptic Treatment and Mortality
Battey TW, Falcone GJ, Ayres AM, Schwab K, Viswanathan A, McNamara KA, DiPucchio ZY, Greenberg SM, Sheth KN, Goldstein JN, Rosand J. Confounding by Indication in Retrospective Studies of Intracerebral Hemorrhage: Antiepileptic Treatment and Mortality. Neurocritical Care 2012, 17: 361-366. PMID: 22965324, PMCID: PMC3707622, DOI: 10.1007/s12028-012-9776-z.Peer-Reviewed Original ResearchConceptsIntroductionIntracerebral hemorrhageAED treatmentAntiepileptic drugsCohort of patientsAntiepileptic treatmentRankin scoreICH locationIntracerebral hemorrhageRetrospective studyHemorrhage locationClinicians' decisionsResultsMultivariate analysisRetrospective analysisSupratentorial regionFatal diseaseConclusionThese resultsMortalityPatientsConflicting resultsTreatmentTreatment effectsHemorrhageCohortAssociationAdequate power