2020
Intestinal Virome in Patients With Alcoholic Hepatitis
Jiang L, Lang S, Duan Y, Zhang X, Gao B, Chopyk J, Schwanemann LK, Ventura‐Cots M, Bataller R, Bosques‐Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Ho SB, Louvet A, Lucey MR, Mathurin P, Garcia‐Tsao G, Kisseleva T, Brenner DA, Tu XM, Stärkel P, Pride D, Fouts DE, Schnabl B. Intestinal Virome in Patients With Alcoholic Hepatitis. Hepatology 2020, 72: 2182-2196. PMID: 32654263, PMCID: PMC8159727, DOI: 10.1002/hep.31459.Peer-Reviewed Original ResearchConceptsAlcohol-associated liver diseaseAlcohol use disorderAlcoholic hepatitisDisease severityEnd-stage liver disease (MELD) scoreFecal samplesLiver Disease scoreMulticenter observational studyVirus-like particlesHigher median ModelIntestinal viromeLiver diseaseSevere manifestationsAntibiotic treatmentObservational studyDisease scoreUse disordersPatientsHigh mortalityViral diversityGut bacteriaViral microbiomeMortalitySeverityHepatitis
2005
Bacterial translocation (BT) in cirrhosis
Wiest R, Garcia‐Tsao G. Bacterial translocation (BT) in cirrhosis. Hepatology 2005, 41: 422-433. PMID: 15723320, DOI: 10.1002/hep.20632.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsBacterial TranslocationDecontaminationHumansImmunity, InnateIntestinal MucosaIntestinesLiver CirrhosisNitric OxideProbioticsConceptsComplications of cirrhosisBacterial translocationPrevention of BTMucosal barrier functionAdaptive immune responsesPrevention of infectionNew therapeutic targetsImmunological defense mechanismsHuman cirrhosisIntestinal pathophysiologyCirrhosisImmune responseTherapeutic approachesIntestinal floraTherapeutic targetAnatomical sitesGut floraBarrier functionComplicationsMultiple mechanismsPathogenesisPreventionCurrent knowledgeDefense mechanismsAlterations