2017
Chapter 36 Ascites
Garcia-Tsao G. Chapter 36 Ascites. 2017, 475-484. DOI: 10.1016/b978-0-12-804274-8.00036-9.Peer-Reviewed Educational MaterialsRefractory ascitesCommon decompensating eventNew-onset ascitesSodium-retaining systemsFirst-line therapyDevelopment of ascitesCause of deathPortal hypertensionRenal failureSodium retentionPathophysiological mechanismsOvert infectionAscitesPathogenic cascadeHigh mortalityVasodilatationEarly placementPatientsCirrhosisDeathHypertensionTherapyInfectionMortality
2016
Approach to the Patient with Ascites and Its Complications
Garcia‐Tsao G. Approach to the Patient with Ascites and Its Complications. 2016, 447-458. DOI: 10.1002/9781118512104.ch55.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsLarge-volume paracentesisSpontaneous bacterial peritonitisNew-onset ascitesPresence of ascitesAcute renal failureFirst-line therapyMainstay of therapySerial large-volume paracentesisEtiology of ascitesAccumulation of fluidHepatorenal syndromePeritoneal malignancyAbdominal ultrasonographyRefractory ascitesSodium restrictionHepatic hydrothoraxLine therapyRenal failureBacterial peritonitisHeart failureDecompensated stageCirrhotic ascitesCommon causePeritoneal cavityAscites
2012
The Combination of Octreotide and Midodrine Is Not Superior to Albumin in Preventing Recurrence of Ascites After Large-Volume Paracentesis
Bari K, Miñano C, Shea M, Inayat IB, Hashem HJ, Gilles H, Heuman D, Garcia–Tsao G. The Combination of Octreotide and Midodrine Is Not Superior to Albumin in Preventing Recurrence of Ascites After Large-Volume Paracentesis. Clinical Gastroenterology And Hepatology 2012, 10: 1169-1175. PMID: 22801062, PMCID: PMC3678262, DOI: 10.1016/j.cgh.2012.06.027.Peer-Reviewed Original ResearchConceptsPostparacentesis circulatory dysfunctionRecurrence of ascitesVasoconstrictor groupAlbumin groupRefractory ascitesAscites recurrenceCombination of midodrineCombination of octreotidePlacebo-controlled trialLarge-volume paracentesisEffective blood volumeTreatment of choiceSingle intravenous doseOral midodrinePreventing RecurrenceRenal failureCirculatory dysfunctionMedian timeSerum levelsIntravenous doseIntramuscular injectionIntravenous administrationAscitesMidodrineBlood volume
2008
Acute kidney injury in cirrhosis
Garcia‐Tsao G, Parikh CR, Viola A. Acute kidney injury in cirrhosis. Hepatology 2008, 48: 2064-2077. PMID: 19003880, DOI: 10.1002/hep.22605.Peer-Reviewed Original ResearchConceptsAcute kidney injuryAcute renal failureHepatorenal syndromeKidney injurySerum creatinineSpecific therapyEffective arterial blood volumeUseful bridging therapyAcute tubular necrosisRenal blood flowSpontaneous bacterial peritonitisArterial blood volumeBridging therapyLiver transplantationPrerenal azotemiaRenal dysfunctionRenal failureTubular necrosisBacterial peritonitisVasodilatory stateRelative hypovolemiaVolume repletionCommon causeCirrhosisBlood flowApproach to the Patient with Ascites and Its Complications
Garcia‐Tsao G. Approach to the Patient with Ascites and Its Complications. 2008, 442-466. DOI: 10.1002/9781444300758.ch23.ChaptersA Randomized, Prospective, Double-Blind, Placebo-Controlled Trial of Terlipressin for Type 1 Hepatorenal Syndrome
Sanyal AJ, Boyer T, Garcia–Tsao G, Regenstein F, Rossaro L, Appenrodt B, Blei A, Gülberg V, Sigal S, Teuber P, Group T. A Randomized, Prospective, Double-Blind, Placebo-Controlled Trial of Terlipressin for Type 1 Hepatorenal Syndrome. Gastroenterology 2008, 134: 1360-1368. PMID: 18471513, PMCID: PMC3730280, DOI: 10.1053/j.gastro.2008.02.014.Peer-Reviewed Original ResearchMeSH KeywordsDose-Response Relationship, DrugDouble-Blind MethodFemaleFollow-Up StudiesGermanyHepatorenal SyndromeHumansInjections, IntravenousKidney Function TestsLypressinMaleMiddle AgedProspective StudiesRussiaSeverity of Illness IndexShock, SepticSurvival RateTerlipressinTreatment OutcomeUnited StatesVasoconstrictor AgentsConceptsHRS type 1Type 1 HRSSCr levelsTreatment successDay 14Type 1Total adverse event rateType 1 hepatorenal syndromePlacebo-controlled clinical trialSafety of terlipressinTrial of terlipressinAdvanced liver diseaseFunctional renal failureNonfatal myocardial infarctionSerum creatinine levelsTransplantation-free survivalAdverse event ratesSyndrome type 1Arterial vasoconstrictorHepatorenal syndromeHRS reversalCreatinine levelsRenal failureRenal functionLiver disease
2005
Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club
Wong F, Bernardi M, Balk R, Christman B, Moreau R, Garcia-Tsao G, Patch D, Soriano G, Hoefs J, Navasa M. Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club. Gut 2005, 54: 718. PMID: 15831923, PMCID: PMC1774473, DOI: 10.1136/gut.2004.038679.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGastrointestinal bleedSepsis syndromeBacterial infectionsInternational Ascites ClubElevated D-dimerSystemic inflammatory responseSpontaneous bacterial peritonitisFurther tissue injuryPresence of infectionNitric oxide synthaseTumor necrosis factorUse of antibioticsUse of albuminSubclinical coagulopathyProphylactic antibioticsRenal impairmentCirrhotic patientsLiver dysfunctionRenal failureBacterial peritonitisBacterial translocationD-dimerReticuloendothelial functionProduction of superoxideInflammatory response
2003
Portal hypertension
GarciaTsao G. Portal hypertension. Current Opinion In Internal Medicine 2003, 2: 229-237. DOI: 10.1097/00132980-200302030-00003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPortal hypertensionHyperdynamic circulationPortosystemic encephalopathyAccumulation of neurotoxinsPortal venous inflowSpontaneous bacterial peritonitisEffective blood volumeExtreme vasodilatationHepatorenal syndromeRenal vasoconstrictionSinusoidal hypertensionVasoconstrictive systemsGastroesophageal varicesIntrahepatic resistanceVariceal hemorrhageHemodynamic abnormalitiesRenal failureBacterial peritonitisCommon complicationHepatic insufficiencySodium retentionVenous inflowMain complicationsNeurohumoral systemsLethal infection
2001
Portal hypertension
Garcia-Tsao G. Portal hypertension. Current Opinion In Gastroenterology 2001, 17: 281-290. PMID: 17031170, DOI: 10.1097/00001574-200105000-00012.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPortal hypertensionHyperdynamic circulationPortosystemic encephalopathyAccumulation of neurotoxinsSpontaneous bacterial peritonitisPortal venous inflowEffective blood volumeExtreme vasodilatationHepatorenal syndromeRenal vasoconstrictionSinusoidal hypertensionSplanchnic vasodilatationVasoconstrictive systemsGastroesophageal varicesIntrahepatic resistanceVariceal hemorrhageHemodynamic abnormalitiesRenal failureBacterial peritonitisCommon complicationHepatic insufficiencySodium retentionVenous inflowMain complicationsNeurohumoral systems