Cross-talk between the Akt and NF-κB Signaling Pathways Inhibits MEHP-Induced Germ Cell Apoptosis
Rogers R, Ouellet G, Brown C, Moyer B, Rasoulpour T, Hixon M. Cross-talk between the Akt and NF-κB Signaling Pathways Inhibits MEHP-Induced Germ Cell Apoptosis. Toxicological Sciences 2008, 106: 497-508. PMID: 18755736, PMCID: PMC2581679, DOI: 10.1093/toxsci/kfn186.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosis Regulatory ProteinsBase SequenceBcl-X ProteinBlotting, WesternCarrier ProteinsDiethylhexyl PhthalateDNA PrimersMaleMiceMitochondrial ProteinsNF-kappa BPhosphorylationProto-Oncogene Proteins c-aktReverse Transcriptase Polymerase Chain ReactionSignal TransductionSpermatozoaSuperoxidesTestisConceptsGerm cell apoptosisMono-(2-ethylhexyl) phthalatePI3K/AktCell apoptosisI kappaB alpha proteinNF-kappaBNuclear factor kappa BWild-type miceFactor kappa BNF-kappaB subunitsTwofold increaseGerm cell survivalWild-type testesTesticular injuryLoss of Akt1MEHP exposureP50 mRNAKappa BP65 subunitPostnatal developmentOxidative stressPremature onsetAktMitochondrial target genesTestis