2022
Benefits and harms of oral anticoagulants for atrial fibrillation in nursing home residents with advanced dementia
Ouellet GM, O'Leary JR, Leggett CG, Skinner J, Tinetti ME, Cohen AB. Benefits and harms of oral anticoagulants for atrial fibrillation in nursing home residents with advanced dementia. Journal Of The American Geriatrics Society 2022, 71: 561-568. PMID: 36310367, PMCID: PMC9957933, DOI: 10.1111/jgs.18108.Peer-Reviewed Original ResearchConceptsNursing home residentsAtrial fibrillationAdvanced dementiaHome residentsStroke riskLong-stay nursing home residentsMedicare Part D claimsDementia-related mortalityGuideline-recommended thresholdHarms of anticoagulationRetrospective cohort studyMultivariable survival analysisValvular heart diseaseRisk of deathPart D claimsMonths of lifeMinimum Data SetAnticoagulant discontinuationAnticoagulated individualsMean CHAVASc scoreCause mortalityMultivariable adjustmentOral anticoagulantsCohort study
2021
Presentation, Treatment, and Outcomes of Older Adults Hospitalized for Acute Myocardial Infarction According to Cognitive Status: The SILVER-AMI Study
Hajduk AM, Saczynski JS, Tsang S, Geda ME, Dodson JA, Ouellet GM, Goldberg RJ, Chaudhry SI. Presentation, Treatment, and Outcomes of Older Adults Hospitalized for Acute Myocardial Infarction According to Cognitive Status: The SILVER-AMI Study. The American Journal Of Medicine 2021, 134: 910-917. PMID: 33737057, PMCID: PMC8243828, DOI: 10.1016/j.amjmed.2021.03.003.Peer-Reviewed Original ResearchConceptsSevere cognitive impairmentAcute myocardial infarctionMyocardial infarctionCognitive impairmentOlder acute myocardial infarction patientsCognitive statusMultivariable-adjusted logistic regressionAcute myocardial infarction patientsOlder adultsRoutine cognitive screeningRisk of readmissionMedical record reviewRisk of deathPost-discharge periodMyocardial infarction patientsMyocardial infarction survivorsSILVER-AMI StudyComorbidity burdenHospital readmissionPoor outcomeRecord reviewFunctional statusInfarction patientsUnadjusted analysesInfarction survivors180-day readmission risk model for older adults with acute myocardial infarction: the SILVER-AMI study
Dodson JA, Hajduk AM, Murphy TE, Geda M, Krumholz HM, Tsang S, Nanna MG, Tinetti ME, Ouellet G, Sybrant D, Gill TM, Chaudhry SI. 180-day readmission risk model for older adults with acute myocardial infarction: the SILVER-AMI study. Open Heart 2021, 8: e001442. PMID: 33452007, PMCID: PMC7813425, DOI: 10.1136/openhrt-2020-001442.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionReadmission risk modelSelf-reported health statusMyocardial infarctionFunctional mobilityOlder adultsHealth statusDays of AMIFirst diastolic blood pressureChronic obstructive pulmonary diseaseIschemic ECG changesProspective cohort studyDiastolic blood pressureObstructive pulmonary diseaseLength of stayInitial heart rateFinal risk modelSILVER-AMI StudyRisk modelInitial hemoglobinCohort studyReadmission ratesBlood pressureEjection fractionHeart failure
2020
Risk Model for Decline in Activities of Daily Living Among Older Adults Hospitalized With Acute Myocardial Infarction: The SILVER‐AMI Study
Hajduk AM, Dodson JA, Murphy TE, Tsang S, Geda M, Ouellet GM, Gill TM, Brush JE, Chaudhry SI. Risk Model for Decline in Activities of Daily Living Among Older Adults Hospitalized With Acute Myocardial Infarction: The SILVER‐AMI Study. Journal Of The American Heart Association 2020, 9: e015555. PMID: 33000681, PMCID: PMC7792390, DOI: 10.1161/jaha.119.015555.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionDaily living declineSILVER-AMI StudyDaily livingOlder patientsMonths postdischargeMyocardial infarctionFunctional declineImportant patient-centered outcomesPoor long-term outcomesLonger hospital stayLong-term outcomesPatient-centered outcomesGeriatric impairmentsHospital stayAMI survivorsClinical variablesMean ageMedical recordsRisk factorsRestorative therapyPhysical activityAMI hospitalizationPsychosocial factorsUS hospitals
2017
Care Transitions Between Hospitals and Skilled Nursing Facilities: Perspectives of Sending and Receiving Providers
Britton MC, Ouellet GM, Minges KE, Gawel M, Hodshon B, Chaudhry SI. Care Transitions Between Hospitals and Skilled Nursing Facilities: Perspectives of Sending and Receiving Providers. The Joint Commission Journal On Quality And Patient Safety 2017, 43: 565-572. PMID: 29056176, PMCID: PMC5693352, DOI: 10.1016/j.jcjq.2017.06.004.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAttitude of Health PersonnelCommunicationHospital AdministrationHumansInsurance, Health, ReimbursementInterviews as TopicPatient DischargePatient ReadmissionPatient TransferQualitative ResearchQuality ImprovementRisk FactorsSeverity of Illness IndexSkilled Nursing FacilitiesUnited StatesConceptsSkilled nursing facilitiesCare transitionsNursing facilitiesSNF providersPatient-level risk factorsOptimal care settingAcute medical illnessUnplanned hospital readmissionComprehensive care planCost of careHospital readmissionMedical illnessComplex patientsRisk factorsMedicare patientsCare settingsCare plansPatient complexityHealth care institutionsPatient transferPsychosocial issuesHospitalPatientsSeparate hospitalsCare institutions
2012
Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome
Costa J, Lopes CM, Barsheshet A, Moss AJ, Migdalovich D, Ouellet G, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I. Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome. Heart Rhythm 2012, 9: 892-898. PMID: 22293141, PMCID: PMC3358462, DOI: 10.1016/j.hrthm.2012.01.020.Peer-Reviewed Original ResearchConceptsCardiac eventsLife-threatening cardiac eventsSex-specific risk factorsSex-specific riskAge 40 yearsLife-threatening eventsType 1 long QT syndromeLong QT syndromeRisk stratificationRisk factorsQT intervalHigh riskTime-dependent differencesQT syndromeMultivariate analysisLQT1WomenCombined assessmentKCNQ1 geneDisease-causing mutationsMenRiskOnset of adolescenceMutation-specific informationSCD
2010
Long QT Syndrome in African‐Americans
Fugate T, Moss AJ, Jons C, McNitt S, Mullally J, Ouellet G, Goldenberg I, Zareba W, Robinson JL, Investigators F. Long QT Syndrome in African‐Americans. Annals Of Noninvasive Electrocardiology 2010, 15: 73-76. PMID: 20146785, PMCID: PMC4028024, DOI: 10.1111/j.1542-474x.2009.00342.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic beta-AntagonistsAdultAge DistributionBlack or African AmericanChildChild, PreschoolDeath, Sudden, CardiacFemaleHeart ArrestHumansInfantInfant, NewbornKaplan-Meier EstimateLong QT SyndromeMaleProportional Hazards ModelsRegistriesRisk FactorsSyncopeUnited StatesWhite PeopleYoung AdultConceptsLong QT syndromeClinical courseRisk factorsQT syndromeAfrican AmericansBeta-blocker therapyCardiac event rateComparable risk factorsKaplan-Meier timeSudden cardiac deathAge 40 yearsAfrican American patientsCox regression modelInternational LQTS RegistryOccurrence of syncopeRisk factor evaluationDecade of birthCardiac eventsCardiac deathCox analysisCardiac arrestLQTS RegistryMedical historyRacial groupsLQTS patients
2009
Influence of Diabetes Mellitus on Outcome in Patients Over 40 Years of Age With the Long QT Syndrome
Ouellet G, Moss AJ, Jons C, McNitt S, Mullally J, Fugate T, Goldenberg I, Zareba W, Robinson JL, Registry I. Influence of Diabetes Mellitus on Outcome in Patients Over 40 Years of Age With the Long QT Syndrome. The American Journal Of Cardiology 2009, 105: 87-89. PMID: 20102896, PMCID: PMC2813216, DOI: 10.1016/j.amjcard.2009.08.657.Peer-Reviewed Original ResearchConceptsYears of ageFirst cardiac eventLong QT syndromeCardiac eventsQTc intervalRisk factorsAdult patientsDiabetes mellitusQT syndromeEnd pointIndependent mortality riskOral diabetic medicationsProlonged QTc intervalImpact of diabetesDevelopment of diabetesBeats/minInternational Long QT Syndrome RegistryCause mortalityDiabetic medicationsOlder patientsStudy populationVentricular repolarizationMortality riskHeart rateCox modelClinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During Infancy
Spazzolini C, Mullally J, Moss AJ, Schwartz PJ, McNitt S, Ouellet G, Fugate T, Goldenberg I, Jons C, Zareba W, Robinson JL, Ackerman MJ, Benhorin J, Crotti L, Kaufman ES, Locati EH, Qi M, Napolitano C, Priori SG, Towbin JA, Vincent GM. Clinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During Infancy. Journal Of The American College Of Cardiology 2009, 54: 832-837. PMID: 19695463, PMCID: PMC3517782, DOI: 10.1016/j.jacc.2009.05.029.Peer-Reviewed Original ResearchConceptsSudden cardiac deathLong QT syndromeCardiac eventsQT syndromeHeart rateClinical implicationsFirst yearBeta-blocker therapyHigh-risk subsetInternational LQTS RegistryBeats/minAge 1 yearYears of lifeHazard ratioCardiac deathSyncopal episodesCardiac arrestLQTS RegistryFemale sexPrognostic aspectsQT intervalStudy populationHigh riskPatientsSyndrome