2022
The association between beta‐blockers and outcomes in patients with heart failure and concurrent Alzheimer's disease and related dementias
Gilstrap L, Cohen A, Ouellet GM, Goyal P, Gladders B, Flint D, Skinner J. The association between beta‐blockers and outcomes in patients with heart failure and concurrent Alzheimer's disease and related dementias. Journal Of The American Geriatrics Society 2022, 71: 404-413. PMID: 36240493, DOI: 10.1111/jgs.18086.Peer-Reviewed Original ResearchConceptsHigh riskBB useHeart failureAlzheimer's diseaseLong-term mortality ratesConcurrent Alzheimer's diseaseBeta-blocker useReduced ejection fractionMedicare Part ARisk/benefitBB therapyEjection fractionContemporary patientsHFrEFHigh prevalenceSimilar riskMortality ratePatientsCognitive impairmentMortalityDiseaseADRDRiskTherapyOutcomes
2012
Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome
Costa J, Lopes CM, Barsheshet A, Moss AJ, Migdalovich D, Ouellet G, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I. Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome. Heart Rhythm 2012, 9: 892-898. PMID: 22293141, PMCID: PMC3358462, DOI: 10.1016/j.hrthm.2012.01.020.Peer-Reviewed Original ResearchConceptsCardiac eventsLife-threatening cardiac eventsSex-specific risk factorsSex-specific riskAge 40 yearsLife-threatening eventsType 1 long QT syndromeLong QT syndromeRisk stratificationRisk factorsQT intervalHigh riskTime-dependent differencesQT syndromeMultivariate analysisLQT1WomenCombined assessmentKCNQ1 geneDisease-causing mutationsMenRiskOnset of adolescenceMutation-specific informationSCD
2011
Mutation and gender-specific risk in type 2 long QT syndrome: Implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome
Migdalovich D, Moss AJ, Lopes CM, Costa J, Ouellet G, Barsheshet A, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I. Mutation and gender-specific risk in type 2 long QT syndrome: Implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome. Heart Rhythm 2011, 8: 1537-1543. PMID: 21440677, PMCID: PMC4028036, DOI: 10.1016/j.hrthm.2011.03.049.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildChild, PreschoolChi-Square DistributionDeath, Sudden, CardiacERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsFemaleHeart ArrestHumansInfantInfant, NewbornLong QT SyndromeMaleMutationProbabilityProportional Hazards ModelsRegistriesRisk AssessmentSex FactorsStatistics, NonparametricSurvival AnalysisConceptsLife-threatening cardiac eventsCardiac eventsLong QT syndromeGender-specific riskRisk stratificationQT syndromeKCNH2 channelsImproved risk stratificationType 2 long QT syndromeAge 40 yearsLife-threatening eventsLQT2 womenFemale patientsHigh riskLQT2 patientsTime-dependent differencesMultivariate analysisPatientsCombined assessmentCumulative probabilityWomenDisease-causing mutationsLoop mutationsMenRisk
2009
Clinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During Infancy
Spazzolini C, Mullally J, Moss AJ, Schwartz PJ, McNitt S, Ouellet G, Fugate T, Goldenberg I, Jons C, Zareba W, Robinson JL, Ackerman MJ, Benhorin J, Crotti L, Kaufman ES, Locati EH, Qi M, Napolitano C, Priori SG, Towbin JA, Vincent GM. Clinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During Infancy. Journal Of The American College Of Cardiology 2009, 54: 832-837. PMID: 19695463, PMCID: PMC3517782, DOI: 10.1016/j.jacc.2009.05.029.Peer-Reviewed Original ResearchConceptsSudden cardiac deathLong QT syndromeCardiac eventsQT syndromeHeart rateClinical implicationsFirst yearBeta-blocker therapyHigh-risk subsetInternational LQTS RegistryBeats/minAge 1 yearYears of lifeHazard ratioCardiac deathSyncopal episodesCardiac arrestLQTS RegistryFemale sexPrognostic aspectsQT intervalStudy populationHigh riskPatientsSyndrome