2022
Regional gene expression patterns are associated with task‐specific brain activation during reward and emotion processing measured with functional MRI
Komorowski A, Murgaš M, Vidal R, Singh A, Gryglewski G, Kasper S, Wiltfang J, Lanzenberger R, Goya‐Maldonado R. Regional gene expression patterns are associated with task‐specific brain activation during reward and emotion processing measured with functional MRI. Human Brain Mapping 2022, 43: 5266-5280. PMID: 35796185, PMCID: PMC9812247, DOI: 10.1002/hbm.26001.Peer-Reviewed Original Research
2021
The Influence of Acute SSRI Administration on White Matter Microstructure in Patients Suffering From Major Depressive Disorder and Healthy Controls
Seiger R, Gryglewski G, Klöbl M, Kautzky A, Godbersen GM, Rischka L, Vanicek T, Hienert M, Unterholzner J, Silberbauer LR, Michenthaler P, Handschuh P, Hahn A, Kasper S, Lanzenberger R. The Influence of Acute SSRI Administration on White Matter Microstructure in Patients Suffering From Major Depressive Disorder and Healthy Controls. The International Journal Of Neuropsychopharmacology 2021, 24: 542-550. PMID: 33667309, PMCID: PMC8299824, DOI: 10.1093/ijnp/pyab008.Peer-Reviewed Original ResearchMeSH KeywordsAdultDepressive Disorder, MajorDiffusion Tensor ImagingFemaleHumansLongitudinal StudiesMaleSelective Serotonin Reuptake InhibitorsWhite MatterYoung AdultConceptsSelective serotonin reuptake inhibitorsMajor depressive disorderSSRI administrationDepressive disorderAxial diffusivityRadial diffusivityMean diffusivityFractional anisotropySerotonin transporterInterventional longitudinal studySerotonin reuptake inhibitorsLevels of serotoninWM microstructureAcute SSRI administrationTract-based spatial statisticsWhite matter alterationsAnterior corona radiataBrain WM microstructureCross-over designAntidepressant therapySSRI treatmentReuptake inhibitorsWhite matter microstructureRepeated-measures ANOVA modelsExternal capsule
2019
Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study
Kraus C, Seiger R, Pfabigan D, Sladky R, Tik M, Paul K, Woletz M, Gryglewski G, Vanicek T, Komorowski A, Kasper S, Lamm C, Windischberger C, Lanzenberger R. Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study. The International Journal Of Neuropsychopharmacology 2019, 22: 513-522. PMID: 31175352, PMCID: PMC6672627, DOI: 10.1093/ijnp/pyz030.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAffectAntidepressive Agents, Second-GenerationAustriaCitalopramDepressive Disorder, MajorDrug SubstitutionFemaleHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedPredictive Value of TestsRemission InductionSelective Serotonin Reuptake InhibitorsSerotonin and Noradrenaline Reuptake InhibitorsTreatment OutcomeVenlafaxine HydrochlorideYoung AdultConceptsMajor depressive disorderDepressive disorderHippocampal subfieldsSubfield volumesAntidepressant treatmentHealthy controlsHippocampal-amygdaloid transition areaMajor depressive disorder patientsOpen-label studyMagnetic resonance imaging studyDepressive disorder patientsHippocampal formation volumeStructural magnetic resonance imagingHippocampal volume changesLower baseline volumesTreatment-related changesResonance imaging studyMagnetic resonance imagingMeasurement time pointsSerotonergic antidepressantsWeeks treatmentAcute patientsRight subiculumUnmedicated patientsBaseline volume
2017
The influence of the rs6295 gene polymorphism on serotonin-1A receptor distribution investigated with PET in patients with major depression applying machine learning
Kautzky A, James GM, Philippe C, Baldinger-Melich P, Kraus C, Kranz GS, Vanicek T, Gryglewski G, Wadsak W, Mitterhauser M, Rujescu D, Kasper S, Lanzenberger R. The influence of the rs6295 gene polymorphism on serotonin-1A receptor distribution investigated with PET in patients with major depression applying machine learning. Translational Psychiatry 2017, 7: e1150-e1150. PMID: 28608854, PMCID: PMC5537636, DOI: 10.1038/tp.2017.108.Peer-Reviewed Original Research
2014
Meta-Analysis of Molecular Imaging of Serotonin Transporters in Major Depression
Gryglewski G, Lanzenberger R, Kranz GS, Cumming P. Meta-Analysis of Molecular Imaging of Serotonin Transporters in Major Depression. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 1096-1103. PMID: 24802331, PMCID: PMC4083395, DOI: 10.1038/jcbfm.2014.82.Peer-Reviewed Original ResearchMeSH KeywordsBrainDepressive Disorder, MajorHumansPositron-Emission TomographySerotoninSerotonin Plasma Membrane Transport ProteinsTomography, Emission-Computed, Single-PhotonConceptsMajor depressive disorderSerotonin selective reuptake inhibitorsBrains of patientsSeverity of depressionMolecular imaging findingsPositron emission tomographySerotonin reuptake sitesSingle photon emissionMore severe reductionsSignificant comorbiditiesReuptake inhibitorsImaging findingsMDD patientsControl subjectsMonoamine theoryReuptake sitesDepressive disorderSerotonergic neurotransmissionMajor depressionMolecular imaging studiesStudy populationCingulate cortexMeta-AnalysisEmission tomographyImaging studies