2019
Changes in White Matter Microstructure After Electroconvulsive Therapy for Treatment-Resistant Depression
Gryglewski G, Seiger R, Baldinger-Melich P, Unterholzner J, Spurny B, Vanicek T, Hahn A, Kasper S, Frey R, Lanzenberger R. Changes in White Matter Microstructure After Electroconvulsive Therapy for Treatment-Resistant Depression. The International Journal Of Neuropsychopharmacology 2019, 23: 20-25. PMID: 31740958, PMCID: PMC7064047, DOI: 10.1093/ijnp/pyz059.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultDepressive Disorder, Treatment-ResistantDiffusion Tensor ImagingElectroconvulsive TherapyFemaleHumansInternal CapsuleMaleMiddle AgedWhite MatterYoung AdultConceptsTreatment-resistant depressionElectroconvulsive therapyWhite matter microstructureRight unilateral electroconvulsive therapyDiffusivity metricsUnipolar treatment-resistant depressionPoor antidepressant responseEffective therapeutic optionUnilateral electroconvulsive therapyDiffusion tensor imaging sequencesElectrode placementTract-based spatial statisticsAntidepressant responseClinical outcomesTherapeutic optionsInternal capsuleRepeated-measures ANOVAPosterior limbTreatment responseMagnetic resonanceElectrical stimulationTherapyAxial diffusivityLeft hemisphereWarrants investigationThe effect of electroconvulsive therapy on cerebral monoamine oxidase A expression in treatment-resistant depression investigated using positron emission tomography
Baldinger-Melich P, Gryglewski G, Philippe C, James GM, Vraka C, Silberbauer L, Balber T, Vanicek T, Pichler V, Unterholzner J, Kranz GS, Hahn A, Winkler D, Mitterhauser M, Wadsak W, Hacker M, Kasper S, Frey R, Lanzenberger R. The effect of electroconvulsive therapy on cerebral monoamine oxidase A expression in treatment-resistant depression investigated using positron emission tomography. Brain Stimulation 2019, 12: 714-723. PMID: 30635228, DOI: 10.1016/j.brs.2018.12.976.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainDepressive Disorder, Treatment-ResistantElectroconvulsive TherapyFemaleHumansMaleMiddle AgedMonoamine OxidasePositron-Emission TomographyConceptsElectroconvulsive therapyTRD patientsMAO-A levelsHealthy subjectsPositron emission tomographyTest-retest variabilityMechanism of actionEffective antidepressant treatment strategiesSex-matched healthy subjectsEmission tomographyAntidepressant treatment strategiesMonoamine oxidaseTreatment-resistant depressionTreatment-resistant patientsSerotonin 1A receptorUnmedicated depressed patientsCerebral monoamine oxidasesCerebral MAOAntidepressant pharmacotherapyECT sessionsAntidepressant treatmentDepressed patientsMajor depressionSerotonergic systemTreatment strategies
2018
Structural changes in amygdala nuclei, hippocampal subfields and cortical thickness following electroconvulsive therapy in treatment-resistant depression: longitudinal analysis
Gryglewski G, Baldinger-Melich P, Seiger R, Godbersen GM, Michenthaler P, Klöbl M, Spurny B, Kautzky A, Vanicek T, Kasper S, Frey R, Lanzenberger R. Structural changes in amygdala nuclei, hippocampal subfields and cortical thickness following electroconvulsive therapy in treatment-resistant depression: longitudinal analysis. The British Journal Of Psychiatry 2018, 214: 159-167. PMID: 30442205, PMCID: PMC6383756, DOI: 10.1192/bjp.2018.224.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmygdalaCerebral CortexDepressive Disorder, Treatment-ResistantElectroconvulsive TherapyFemaleHippocampusHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedOrgan SizeTreatment OutcomeConceptsTreatment-resistant depressionElectroconvulsive therapyMagnetic resonance imagingCortical thicknessHippocampal subfieldsAmygdala nucleiHippocampal-amygdaloid transition areaRight unilateral electroconvulsive therapyEffects of ECTHigh-resolution structural magnetic resonance imagingUnipolar treatment-resistant depressionCorticoamygdaloid transition areaPathophysiology of depressionPre-post study designCorrelation of imagingUnilateral electroconvulsive therapyTreatment of choiceStructural magnetic resonance imagingSpecific hippocampal subfieldsSevere mental illnessGrant/research supportStress-related disordersClinical parametersRepeated-measures ANOVADentate gyrus