Increased left dorsolateral prefrontal cortex density following escitalopram intake during relearning: a randomized, placebo-controlled trial in healthy humans
Vanicek T, Reed M, Seiger R, Godbersen G, Klöbl M, Unterholzner J, Spurny-Dworak B, Gryglewski G, Handschuh P, Schmidt C, Kraus C, Stimpfl T, Rupprecht R, Kasper S, Lanzenberger R. Increased left dorsolateral prefrontal cortex density following escitalopram intake during relearning: a randomized, placebo-controlled trial in healthy humans. Therapeutic Advances In Psychopharmacology 2022, 12: 20451253221132085. PMID: 36420117, PMCID: PMC9677158, DOI: 10.1177/20451253221132085.Peer-Reviewed Original ResearchLeft dorsolateral prefrontal cortexAssociative learning taskNon-emotional contentDorsolateral prefrontal cortexVoxel-based morphometry analysisEmotional processingExecutive functionLearning taskNeurobiological processesVoxel-based morphometryPrefrontal cortexBrain plasticityEscitalopram intakeNeural plasticityBrain areasNeuroplastic processesBlood levelsBrain structuresHealthy individualsMorphometry analysisDouble-blind placebo controlGray matterStress-induced dendritic atrophySelective serotonin reuptake inhibitorsPlacebo intake