2019
Hippocampal GABA levels correlate with retrieval performance in an associative learning paradigm
Spurny B, Seiger R, Moser P, Vanicek T, Reed MB, Heckova E, Michenthaler P, Basaran A, Gryglewski G, Klöbl M, Trattnig S, Kasper S, Bogner W, Lanzenberger R. Hippocampal GABA levels correlate with retrieval performance in an associative learning paradigm. NeuroImage 2019, 204: 116244. PMID: 31606475, PMCID: PMC7610791, DOI: 10.1016/j.neuroimage.2019.116244.Peer-Reviewed Original ResearchConceptsHippocampal GABA levelsGABA levelsLong-term depressionLong-term potentiationHealthy participantsChanges of GABAMain inhibitory neurotransmitterMulti-voxel magnetic resonance spectroscopyMemory formationBaseline GABA levelsLongitudinal study designGlutamatergic systemInhibitory neurotransmitterNeuroplastic processesGlutamate concentrationNeural plasticityStudy designGABAAssociative learning paradigmThalamusHippocampusHuman brainInsulaNeurochemical underpinningsBrain
2018
Parcellation of the Human Cerebral Cortex Based on Molecular Targets in the Serotonin System Quantified by Positron Emission Tomography In vivo
James GM, Gryglewski G, Vanicek T, Berroterán-Infante N, Philippe C, Kautzky A, Nics L, Vraka C, Godbersen GM, Unterholzner J, Sigurdardottir HL, Spies M, Seiger R, Kranz GS, Hahn A, Mitterhauser M, Wadsak W, Bauer A, Hacker M, Kasper S, Lanzenberger R. Parcellation of the Human Cerebral Cortex Based on Molecular Targets in the Serotonin System Quantified by Positron Emission Tomography In vivo. Cerebral Cortex 2018, 29: 372-382. PMID: 30357321, PMCID: PMC6294402, DOI: 10.1093/cercor/bhy249.Peer-Reviewed Original ResearchConceptsPositron emission tomographyEmission tomographySerotonin neurotransmitter systemSerotonin 1ACerebral cortexEnzyme monoamine oxidase AMonoamine oxidase ANeurotransmitter systemsSerotonin systemPsychotropic drugsNeuropsychiatric disordersBrain functionHealthy participantsSerotonin transporterMolecular imaging dataMolecular targetsMolecular profileOxidase AWhole-brain coverageCortexParcellationTomographyDefined clustersClose associationImaging data