Quantification of Task-Specific Glucose Metabolism with Constant Infusion of 18F-FDG
Hahn A, Gryglewski G, Nics L, Hienert M, Rischka L, Vraka C, Sigurdardottir H, Vanicek T, James GM, Seiger R, Kautzky A, Silberbauer L, Wadsak W, Mitterhauser M, Hacker M, Kasper S, Lanzenberger R. Quantification of Task-Specific Glucose Metabolism with Constant Infusion of 18F-FDG. Journal Of Nuclear Medicine 2016, 57: 1933-1940. PMID: 27390156, DOI: 10.2967/jnumed.116.176156.Peer-Reviewed Original ResearchConceptsBaseline glucose metabolismTask-specific changesGlucose metabolismTime-activity curvesConstant infusionBolus applicationF-FDGBlood samplingBaseline metabolismPatlak plotVenous blood samplesCerebral metabolic rateVenous blood samplingGeneral linear modelHigh intrasubject variabilityMultimodal brain imagingArterial blood samplingMotor cortexHealthy subjectsCMRgluRegional time-activity curvesRight thumbArterial samplesBlood samplesDefault mode regions