2018
Reduced task durations in functional PET imaging with [18F]FDG approaching that of functional MRI
Rischka L, Gryglewski G, Pfaff S, Vanicek T, Hienert M, Klöbl M, Hartenbach M, Haug A, Wadsak W, Mitterhauser M, Hacker M, Kasper S, Lanzenberger R, Hahn A. Reduced task durations in functional PET imaging with [18F]FDG approaching that of functional MRI. NeuroImage 2018, 181: 323-330. PMID: 29966719, DOI: 10.1016/j.neuroimage.2018.06.079.Peer-Reviewed Original ResearchConceptsFunctional MRIPercent signal changeTask-specific changesMotor cortexGlucose metabolismIpsilateral motor cortexImaging modalitiesSupplementary motor areaSecondary visual cortexHybrid PET/MRI scannerConstant infusion protocolTask-specific activationInfusion protocolDifferent activation patternsHealthy subjectsMotor areaArterial samplesCMRgluConstant infusionDifferent imaging modalitiesTracer uptakeVisual cortexSignificant associationUnspecific activationPET/MRI scanner
2016
Quantification of Task-Specific Glucose Metabolism with Constant Infusion of 18F-FDG
Hahn A, Gryglewski G, Nics L, Hienert M, Rischka L, Vraka C, Sigurdardottir H, Vanicek T, James GM, Seiger R, Kautzky A, Silberbauer L, Wadsak W, Mitterhauser M, Hacker M, Kasper S, Lanzenberger R. Quantification of Task-Specific Glucose Metabolism with Constant Infusion of 18F-FDG. Journal Of Nuclear Medicine 2016, 57: 1933-1940. PMID: 27390156, DOI: 10.2967/jnumed.116.176156.Peer-Reviewed Original ResearchConceptsBaseline glucose metabolismTask-specific changesGlucose metabolismTime-activity curvesConstant infusionBolus applicationF-FDGBlood samplingBaseline metabolismPatlak plotVenous blood samplesCerebral metabolic rateVenous blood samplingGeneral linear modelHigh intrasubject variabilityMultimodal brain imagingArterial blood samplingMotor cortexHealthy subjectsCMRgluRegional time-activity curvesRight thumbArterial samplesBlood samplesDefault mode regions