Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes
Mason GF, Petersen KF, Lebon V, Rothman DL, Shulman GI. Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes. Diabetes 2006, 55: 929-934. PMID: 16567513, PMCID: PMC2995526, DOI: 10.2337/diabetes.55.04.06.db05-1325.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAdultBiological TransportBrainDiabetes Mellitus, Type 1FemaleGamma-Aminobutyric AcidGlutamic AcidHumansInsulinKineticsMaleReference ValuesConceptsType 1 diabetesDiabetic subjectsControl subjectsType 1 diabetic subjectsInsulin-induced hypoglycemiaNondiabetic control subjectsMonocarboxylic acid transportBrain utilizationSimilar twofold increaseBrain energeticsHypoglycemiaType 1DiabetesOxidative metabolismNonglucose substratesBrainMetabolic substratesUpregulationPatientsAcid transportTwofold increaseSubjectsMagnetic resonance spectroscopyLactateMetabolism