2009
Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy
Boumezbeur F, Mason GF, de Graaf RA, Behar KL, Cline GW, Shulman GI, Rothman DL, Petersen KF. Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy. Cerebrovascular And Brain Metabolism Reviews 2009, 30: 211-221. PMID: 19794401, PMCID: PMC2949111, DOI: 10.1038/jcbfm.2009.197.Peer-Reviewed Original ResearchConceptsNeuronal mitochondrial metabolismHealthy agingBrain mitochondrial metabolismElderly subjectsYoung subjectsBrain functionBrain mitochondrial functionGlutamate-glutamine cyclingMitochondrial metabolismVivo magnetic resonance spectroscopyAge-related changesChronic reductionLabeling of glutamineGlutamate concentrationYoung volunteersBiologic basisMagnetic resonance spectroscopyMitochondrial functionMetabolismSubjectsIndividual subjectsResonance spectroscopyTricarboxylic acid cycleCycle fluxAging
2001
Differential increase in cerebral cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitro
Novotny E, Ariyan C, Mason G, O’Reilly J, Haddad G, Behar K. Differential increase in cerebral cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitro. Brain Research 2001, 888: 193-202. PMID: 11150475, DOI: 10.1016/s0006-8993(00)03051-1.Peer-Reviewed Original ResearchConceptsGlucose oxidative metabolismNeocortical slicesOxidative metabolismRat postnatal developmentCortical glutamateCerebral cortexCortex maturesPostnatal dayPostnatal developmentAge groupsCortexMitochondrial TCA cycleGreater increaseVivoGlucose oxidationTCA cycle fluxDifferential increaseAcid extractsMetabolismSlicesDeafferentiationCycle fluxRats