2006
Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes
Mason GF, Petersen KF, Lebon V, Rothman DL, Shulman GI. Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes. Diabetes 2006, 55: 929-934. PMID: 16567513, PMCID: PMC2995526, DOI: 10.2337/diabetes.55.04.06.db05-1325.Peer-Reviewed Original ResearchConceptsType 1 diabetesDiabetic subjectsControl subjectsType 1 diabetic subjectsInsulin-induced hypoglycemiaNondiabetic control subjectsMonocarboxylic acid transportBrain utilizationSimilar twofold increaseBrain energeticsHypoglycemiaType 1DiabetesOxidative metabolismNonglucose substratesBrainMetabolic substratesUpregulationPatientsAcid transportTwofold increaseSubjectsMagnetic resonance spectroscopyLactateMetabolism
1995
Proton nuclear magnetic resonance spectroscopic imaging of human temporal lobe epilepsy at 4.1 T
Hetherington H, Kuzniecky R, Pan J, Mason G, Morawetz R, Harris C, Faught E, Vaughan T, Pohost G. Proton nuclear magnetic resonance spectroscopic imaging of human temporal lobe epilepsy at 4.1 T. Annals Of Neurology 1995, 38: 396-404. PMID: 7668825, DOI: 10.1002/ana.410380309.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyMagnetic resonance spectroscopic imagingProton magnetic resonance spectroscopic imagingLobe epilepsyAcetylaspartate ratioMetabolic abnormalitiesEpileptic focusBilateral independent seizure onsetHuman temporal lobe epilepsyIntractable temporal lobe epilepsyIntracranial electroencephalographic studiesOperated temporal lobeNormal control subjectsDistinctive metabolic profileMagnetic resonance imagingContralateral abnormalitiesControl subjectsSeizure onsetCholine levelsHealthy volunteersN-acetylaspartateTemporal lobePatientsEpilepsyResonance imaging