2018
Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis
Hendricks W, Zismann V, Sivaprakasam K, Legendre C, Poorman K, Tembe W, Perdigones N, Kiefer J, Liang W, DeLuca V, Stark M, Ruhe A, Froman R, Duesbery N, Washington M, Aldrich J, Neff M, Huentelman M, Hayward N, Brown K, Thamm D, Post G, Khanna C, Davis B, Breen M, Sekulic A, Trent J. Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis. PLOS Genetics 2018, 14: e1007589. PMID: 30188888, PMCID: PMC6126841, DOI: 10.1371/journal.pgen.1007589.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CycleCell ProliferationComparative Genomic HybridizationDNA Mutational AnalysisDog DiseasesDogsFemaleMaleMelanomaMutationProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)Receptor-Like Protein Tyrosine Phosphatases, Class 3Signal TransductionSkin NeoplasmsTissue Array AnalysisConceptsLow point mutation ratePowerful comparative modelComparative genomic analysisCell cycle controlPoint mutation rateSingle nucleotide polymorphism arrayNucleotide polymorphism arrayWhole-genome sequencingArray comparative genomic hybridizationHuman melanomaComparative genomic hybridizationGenomic analysisRNA sequencingCycle controlGenome sequencingMutation rateGenomic landscapePolymorphism arrayCopy numberMutational landscapeMutational signaturesGenomic hybridizationRecurrent alterationsMulti-platform analysisMutations
2001
Clinicopathologic and Electron Microscopic Study of Cutaneous Neuroendocrine (Merkel Cell) Carcinoma in a Cat with Comparisons to Human and Canine Tumors
Patnaik A, Post G, Erlandson R. Clinicopathologic and Electron Microscopic Study of Cutaneous Neuroendocrine (Merkel Cell) Carcinoma in a Cat with Comparisons to Human and Canine Tumors. Veterinary Pathology 2001, 38: 553-556. PMID: 11572564, DOI: 10.1354/vp.38-5-553.Peer-Reviewed Original ResearchConceptsMerkel cell tumorNeuroendocrine carcinomaCell tumorsMalignant neuroendocrine carcinomasCutaneous neuroendocrine carcinomaElectron microscopic findingsBasis of morphologicMaine Coon catsSurgical excisionMicroscopic findingsTumor malignancyCanine tumorsBenign natureTumorsMalignancyElectron microscopic studyCarcinomaCatsMicroscopic studyClinicopathologicHumansExcisionDiagnosisDogs